XPA [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= XPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XPA
  * **<color #00a2e8>Official Name</color>**: XPA, DNA damage recognition and repair factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7507|7507]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23025|P23025]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611153|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. {ECO:0000269|PubMed:19197159}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|XPA C|
|XPA N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleotide-excision repair involved in interstrand cross-link repair|
|nucleotide-excision repair factor 1 complex|
|UV protection|
|UV-damage excision repair|
|DNA replication factor A complex|
|nucleotide-excision repair, preincision complex stabilization|
|nucleotide-excision repair, DNA duplex unwinding|
|nucleotide-excision repair, DNA incision, 3-to lesion|
|nucleotide-excision repair, DNA damage recognition|
|response to auditory stimulus|
|global genome nucleotide-excision repair|
|nucleotide-excision repair, preincision complex assembly|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|base-excision repair|
|nucleotide-excision repair, DNA incision|
|interstrand cross-link repair|
|damaged DNA binding|
|intercellular bridge|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|transcription-coupled nucleotide-excision repair|
|multicellular organism growth|
|cellular response to UV|
|nucleotide-excision repair|
|DNA duplex unwinding|
|cellular response to light stimulus|
|DNA geometric change|
|response to UV|
|intrinsic apoptotic signaling pathway|
|protein localization to nucleus|
|cellular response to radiation|
|protein-DNA complex assembly|
|response to mechanical stimulus|
|protein-DNA complex subunit organization|
|protein domain specific binding|
|positive regulation of protein complex assembly|
|apoptotic signaling pathway|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of autophagy|
|response to oxidative stress|
|developmental growth|
|growth|
|response to radiation|
|regulation of protein complex assembly|
|response to toxic substance|
|DNA repair|
|positive regulation of cellular component biogenesis|
|protein localization to organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|protein homodimerization activity|
|apoptotic process|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|programmed cell death|
|chromosome organization|
|cell death|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|intracellular signal transduction|
|cellular response to stress|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.72|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15877
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XPA Expression in NALM6 Cells: 4.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>