YEATS2 [The Human Chemical-Genetic Interaction Map Project]

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======= YEATS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YEATS2
  * **<color #00a2e8>Official Name</color>**: YEATS domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55689|55689]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULM3|Q9ULM3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YEATS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YEATS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613373|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|YEATS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modification-dependent protein binding|
|Ada2/Gcn5/Ada3 transcription activator complex|
|TBP-class protein binding|
|histone H3 acetylation|
|mitotic spindle|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|histone binding|
|protein acetylation|
|protein acylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.26|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.25|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.2|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.82|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.81|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.73|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.74|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.83|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.88|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.92|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.04|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.15|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.97|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zzz3|ZZZ3]]|0.589|
|[[:human genes:t:tada2a|TADA2A]]|0.542|
|[[:human genes:h:heatr3|HEATR3]]|0.454|
|[[:human genes:w:wdr5|WDR5]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 52/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|3/25|
|breast|3/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|0/15|
|kidney|1/21|
|liver|1/20|
|lung|6/75|
|lymphocyte|0/14|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3035
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YEATS2 Expression in NALM6 Cells: 7.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>