YIPF5 [The Human Chemical-Genetic Interaction Map Project]

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======= YIPF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YIPF5
  * **<color #00a2e8>Official Name</color>**: Yip1 domain family member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81555|81555]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969M3|Q969M3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YIPF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YIPF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611483|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in transport between endoplasmic reticulum and Golgi. {ECO:0000269|PubMed:11489904, ECO:0000269|PubMed:15611160}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Yip1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of ER to Golgi vesicle-mediated transport|
|endoplasmic reticulum exit site|
|COPII-coated ER to Golgi transport vesicle|
|regulation of intracellular transport|
|regulation of vesicle-mediated transport|
|intracellular membrane-bounded organelle|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|endoplasmic reticulum|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-3.75|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.17|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.05|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.99|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.46|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.18|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.98|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.92|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.86|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.79|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.77|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ier3ip1|IER3IP1]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16176
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YIPF5 Expression in NALM6 Cells: 4.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>