YIPF6 [The Human Chemical-Genetic Interaction Map Project]

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======= YIPF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YIPF6
  * **<color #00a2e8>Official Name</color>**: Yip1 domain family member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=286451|286451]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EC8|Q96EC8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YIPF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YIPF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300996|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269|PubMed:28286305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Yip1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi medial cisterna|
|Golgi trans cisterna|
|intestinal epithelial cell development|
|intestinal epithelial cell differentiation|
|COPII-coated ER to Golgi transport vesicle|
|columnar/cuboidal epithelial cell development|
|cis-Golgi network|
|columnar/cuboidal epithelial cell differentiation|
|digestive tract development|
|digestive system development|
|trans-Golgi network|
|epithelial cell development|
|Golgi membrane|
|epithelial cell differentiation|
|tube development|
|endoplasmic reticulum|
|identical protein binding|
|epithelium development|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.92|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.57|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.92|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.81|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.78|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.73|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.7|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.91|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.16|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tvp23b|TVP23B]]|0.484|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17827
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YIPF6 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>