ZBTB1 [The Human Chemical-Genetic Interaction Map Project]

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======= ZBTB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZBTB1
  * **<color #00a2e8>Official Name</color>**: zinc finger and BTB domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22890|22890]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2K1|Q9Y2K1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZBTB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZBTB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616578|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of pro-T cell differentiation|
|regulation of pro-T cell differentiation|
|positive regulation of lymphoid progenitor cell differentiation|
|positive regulation of hematopoietic progenitor cell differentiation|
|positive regulation of natural killer cell differentiation|
|regulation of lymphoid progenitor cell differentiation|
|regulation of natural killer cell differentiation|
|mRNA transcription by RNA polymerase II|
|positive regulation of natural killer cell activation|
|K63-linked polyubiquitin modification-dependent protein binding|
|mRNA transcription|
|regulation of natural killer cell activation|
|translesion synthesis|
|thymus development|
|T cell differentiation in thymus|
|positive regulation of T cell mediated immunity|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|regulation of T cell mediated immunity|
|positive regulation of T cell differentiation|
|cellular response to UV|
|regulation of hematopoietic progenitor cell differentiation|
|positive regulation of lymphocyte differentiation|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|B cell differentiation|
|DNA biosynthetic process|
|cellular response to light stimulus|
|positive regulation of leukocyte mediated immunity|
|T cell differentiation|
|regulation of T cell differentiation|
|response to UV|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte mediated immunity|
|B cell activation|
|regulation of adaptive immune response|
|chromatin remodeling|
|regulation of lymphocyte differentiation|
|cellular response to radiation|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|T cell activation|
|lymphocyte differentiation|
|nuclear membrane|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|nuclear body|
|regulation of leukocyte cell-cell adhesion|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of T cell activation|
|leukocyte differentiation|
|protein homooligomerization|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|gland development|
|positive regulation of cell activation|
|response to radiation|
|regulation of hemopoiesis|
|regulation of immune effector process|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|DNA repair|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|regulation of cell adhesion|
|mRNA metabolic process|
|chromatin organization|
|DNA metabolic process|
|innate immune response|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|protein homodimerization activity|
|leukocyte activation|
|defense response to other organism|
|positive regulation of cell differentiation|
|chromosome organization|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-3.65|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-3.44|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-3.3|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-3.28|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-3.14|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-3.02|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.57|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.56|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.51|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.51|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.51|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.45|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.39|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.3|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.28|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.09|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.09|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.03|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.01|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.99|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.95|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.92|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.9|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.9|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.9|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.89|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.85|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.84|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.83|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.82|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.81|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.75|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.74|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.73|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.71|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.7|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.7|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.8|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.39|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15866
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZBTB1 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>