ZC3H18 [The Human Chemical-Genetic Interaction Map Project]

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======= ZC3H18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZC3H18
  * **<color #00a2e8>Official Name</color>**: zinc finger CCCH-type containing 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=124245|124245]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VM9|Q86VM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZC3H18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZC3H18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear speck|
|protein-containing complex|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.61|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.4|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.22|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.14|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.02|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.97|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.86|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.74|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.73|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.74|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.82|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.99|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.01|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|2.47|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13l|MED13L]]|0.496|
|[[:human genes:m:med13|MED13]]|0.482|
|[[:human genes:c:ccnc|CCNC]]|0.467|
|[[:human genes:i:ing5|ING5]]|0.443|
|[[:human genes:h:hdac8|HDAC8]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 147/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|12/28|
|bone|3/26|
|breast|10/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|6/21|
|liver|6/20|
|lung|19/75|
|lymphocyte|5/16|
|ovary|7/26|
|pancreas|5/24|
|peripheral nervous system|6/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 401
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZC3H18 Expression in NALM6 Cells: 7.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>