ZCRB1 [The Human Chemical-Genetic Interaction Map Project]

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======= ZCRB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZCRB1
  * **<color #00a2e8>Official Name</color>**: zinc finger CCHC-type and RNA binding motif containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85437|85437]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TBF4|Q8TBF4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZCRB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZCRB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610750|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U12-type spliceosomal complex|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|zinc ion binding|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.77|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.63|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.61|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.61|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.44|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.35|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.35|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.25|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.23|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.22|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.04|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.99|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.98|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.98|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.97|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.97|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.97|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.96|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.95|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.92|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.91|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.9|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.9|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.79|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.77|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.77|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.75|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.71|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.7|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.72|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.79|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.87|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.01|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.04|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.46|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.61|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.67|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.69|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zrsr2|ZRSR2]]|0.521|
|[[:human genes:f:fh|FH]]|0.505|
|[[:human genes:p:ppp6c|PPP6C]]|0.485|
|[[:human genes:g:gemin6|GEMIN6]]|0.479|
|[[:human genes:l:lsm10|LSM10]]|0.479|
|[[:human genes:g:gemin8|GEMIN8]]|0.465|
|[[:human genes:g:gemin7|GEMIN7]]|0.453|
|[[:human genes:f:fkbpl|FKBPL]]|0.447|
|[[:human genes:r:rabggtb|RABGGTB]]|0.444|
|[[:human genes:t:thg1l|THG1L]]|0.443|
|[[:human genes:c:c15orf41|C15orf41]]|0.443|
|[[:human genes:a:atxn10|ATXN10]]|0.442|
|[[:human genes:a:atic|ATIC]]|0.439|
|[[:human genes:t:tmem242|TMEM242]]|0.431|
|[[:human genes:v:vezt|VEZT]]|0.431|
|[[:human genes:p:ppcdc|PPCDC]]|0.43|
|[[:human genes:p:ppp4c|PPP4C]]|0.43|
|[[:human genes:t:tpk1|TPK1]]|0.429|
|[[:human genes:r:rfk|RFK]]|0.427|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.426|
|[[:human genes:s:slc25a19|SLC25A19]]|0.419|
|[[:human genes:p:pdcd5|PDCD5]]|0.417|
|[[:human genes:c:cxorf56|CXorf56]]|0.416|
|[[:human genes:t:ten1|TEN1]]|0.416|
|[[:human genes:u:uhrf1|UHRF1]]|0.415|
|[[:human genes:b:bcs1l|BCS1L]]|0.415|
|[[:human genes:s:slc25a26|SLC25A26]]|0.415|
|[[:human genes:s:sco2|SCO2]]|0.413|
|[[:human genes:t:tubd1|TUBD1]]|0.41|
|[[:human genes:a:adsl|ADSL]]|0.408|
|[[:human genes:d:dars2|DARS2]]|0.408|
|[[:human genes:t:trmt61a|TRMT61A]]|0.406|
|[[:human genes:s:selrc1|SELRC1]]|0.404|
|[[:human genes:w:wrb|WRB]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 195/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|9/28|
|bone|5/26|
|breast|5/33|
|central nervous system|20/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|1/21|
|liver|6/20|
|lung|23/75|
|lymphocyte|5/16|
|ovary|6/26|
|pancreas|8/24|
|peripheral nervous system|6/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|13/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2711
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZCRB1 Expression in NALM6 Cells: 4.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>