ZDHHC15 [The Human Chemical-Genetic Interaction Map Project]

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======= ZDHHC15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZDHHC15
  * **<color #00a2e8>Official Name</color>**: zinc finger DHHC-type palmitoyltransferase 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=158866|158866]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MV8|Q96MV8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZDHHC15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZDHHC15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300576|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Palmitoyltransferase specific for GAP43 and DLG4/PSD95. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-DHHC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptic vesicle maturation|
|palmitoyltransferase activity|
|peptidyl-L-cysteine S-palmitoylation|
|peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine|
|protein-cysteine S-palmitoyltransferase activity|
|protein palmitoylation|
|peptidyl-cysteine modification|
|protein lipidation|
|lipoprotein biosynthetic process|
|lipoprotein metabolic process|
|protein targeting to membrane|
|protein acylation|
|developmental maturation|
|establishment of protein localization to membrane|
|vesicle organization|
|protein targeting|
|protein localization to membrane|
|Golgi membrane|
|peptidyl-amino acid modification|
|Golgi apparatus|
|intracellular protein transport|
|endoplasmic reticulum|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.94|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.89|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.84|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.82|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.75|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.75|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.91|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.97|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18866
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZDHHC15 Expression in NALM6 Cells: 2.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>