ZEB2 [The Human Chemical-Genetic Interaction Map Project]

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======= ZEB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZEB2
  * **<color #00a2e8>Official Name</color>**: zinc finger E-box binding homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9839|9839]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60315|O60315]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZEB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZEB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605802|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin. {ECO:0000269|PubMed:16061479}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of lens fiber cell differentiation|
|mammillary body development|
|regulation of melanosome organization|
|melanocyte migration|
|mammillary axonal complex development|
|regulation of lens fiber cell differentiation|
|positive regulation of melanocyte differentiation|
|positive regulation of melanin biosynthetic process|
|regulation of melanocyte differentiation|
|corpus callosum morphogenesis|
|positive regulation of secondary metabolite biosynthetic process|
|corticospinal tract morphogenesis|
|positive regulation of pigment cell differentiation|
|regulation of pigment cell differentiation|
|phosphatase regulator activity|
|collateral sprouting|
|positive regulation of developmental pigmentation|
|regulation of melanin biosynthetic process|
|regulation of secondary metabolite biosynthetic process|
|regulation of secondary metabolic process|
|regulation of developmental pigmentation|
|corpus callosum development|
|R-SMAD binding|
|central nervous system projection neuron axonogenesis|
|cell proliferation in forebrain|
|central nervous system neuron axonogenesis|
|developmental pigmentation|
|neural crest cell migration|
|positive regulation of epithelial cell differentiation|
|somitogenesis|
|positive regulation of JUN kinase activity|
|neural precursor cell proliferation|
|diencephalon development|
|neural crest cell development|
|central nervous system neuron development|
|hippocampus development|
|somite development|
|mesenchymal cell development|
|epithelial cell migration|
|stem cell development|
|positive regulation of axonogenesis|
|epithelium migration|
|regulation of JUN kinase activity|
|developmental cell growth|
|neural crest cell differentiation|
|cell growth|
|neural tube closure|
|tube closure|
|pigmentation|
|tissue migration|
|segmentation|
|primary neural tube formation|
|neural tube formation|
|limbic system development|
|developmental growth involved in morphogenesis|
|embryonic epithelial tube formation|
|epithelial tube formation|
|positive regulation of JNK cascade|
|regulation of epithelial cell differentiation|
|morphogenesis of embryonic epithelium|
|tube formation|
|positive regulation of cell morphogenesis involved in differentiation|
|mesenchymal cell differentiation|
|stem cell differentiation|
|neural tube development|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|ameboidal-type cell migration|
|pallium development|
|positive regulation of Wnt signaling pathway|
|central nervous system neuron differentiation|
|regulation of axonogenesis|
|regulation of JNK cascade|
|anterior/posterior pattern specification|
|mesenchyme development|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|nuclear chromatin|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|telencephalon development|
|positive regulation of MAP kinase activity|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|regionalization|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|forebrain development|
|developmental growth|
|growth|
|axon development|
|sequence-specific DNA binding|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of cellular response to stress|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.08|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.06|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.92|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.84|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.71|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.77|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.86|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.92|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|3.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 25/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|6/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1109
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZEB2 Expression in NALM6 Cells: 7.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>