ZFAT [The Human Chemical-Genetic Interaction Map Project]

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======= ZFAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFAT
  * **<color #00a2e8>Official Name</color>**: zinc finger and AT-hook domain containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57623|57623]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P243|Q9P243]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610931|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spongiotrophoblast layer development|
|embryonic placenta development|
|hematopoietic progenitor cell differentiation|
|placenta development|
|in utero embryonic development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|embryo development|
|positive regulation of transcription by RNA polymerase II|
|reproductive process|
|reproduction|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.66|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.66|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.48|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.4|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.2|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.16|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2|
|[[:results:exp539|42°C R08 exp539]]|-1.97|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.91|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.87|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.86|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.82|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.81|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.78|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.72|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.71|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arl1|ARL1]]|0.615|
|[[:human genes:g:gpr107|GPR107]]|0.553|
|[[:human genes:j:jtb|JTB]]|0.548|
|[[:human genes:w:wdr7|WDR7]]|0.548|
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.546|
|[[:human genes:c:cog7|COG7]]|0.469|
|[[:human genes:u:ubap2l|UBAP2L]]|0.449|
|[[:human genes:t:tssc1|TSSC1]]|0.433|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.427|
|[[:human genes:s:slc39a9|SLC39A9]]|0.42|
|[[:human genes:c:c10orf76|C10orf76]]|0.419|
|[[:human genes:p:pi4kb|PI4KB]]|0.417|
|[[:human genes:p:prim1|PRIM1]]|0.415|
|[[:human genes:c:cog5|COG5]]|0.411|
|[[:human genes:a:atp6v1g1|ATP6V1G1]]|0.405|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1735
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFAT Expression in NALM6 Cells: 3.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>