ZFP36L2 [The Human Chemical-Genetic Interaction Map Project]

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======= ZFP36L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFP36L2
  * **<color #00a2e8>Official Name</color>**: ZFP36 ring finger protein like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=678|678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47974|P47974]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFP36L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFP36L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612053|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE- containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13- acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity- joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCCH|
|Tis11B N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to granulocyte macrophage colony-stimulating factor stimulus|
|response to granulocyte macrophage colony-stimulating factor|
|3-UTR-mediated mRNA destabilization|
|definitive hemopoiesis|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|negative regulation of stem cell differentiation|
|somatic stem cell division|
|mRNA 3-UTR AU-rich region binding|
|regulation of B cell differentiation|
|ERK1 and ERK2 cascade|
|mRNA destabilization|
|RNA destabilization|
|stem cell division|
|cellular response to epidermal growth factor stimulus|
|negative regulation of fat cell differentiation|
|T cell differentiation in thymus|
|response to epidermal growth factor|
|positive regulation of mRNA catabolic process|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|somatic stem cell population maintenance|
|mRNA 3-UTR binding|
|positive regulation of mRNA metabolic process|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|regulation of stem cell differentiation|
|regulation of fat cell differentiation|
|negative regulation of translation|
|T cell differentiation|
|stem cell population maintenance|
|maintenance of cell number|
|response to glucocorticoid|
|negative regulation of cellular amide metabolic process|
|cellular response to transforming growth factor beta stimulus|
|response to corticosteroid|
|response to transforming growth factor beta|
|regulation of lymphocyte differentiation|
|regulation of mRNA stability|
|regulation of RNA stability|
|cellular response to steroid hormone stimulus|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|regulation of B cell activation|
|negative regulation of mitotic cell cycle phase transition|
|mRNA catabolic process|
|negative regulation of cell cycle phase transition|
|T cell activation|
|lymphocyte differentiation|
|cellular response to tumor necrosis factor|
|RNA catabolic process|
|response to tumor necrosis factor|
|regulation of leukocyte differentiation|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|response to steroid hormone|
|regulation of mRNA metabolic process|
|leukocyte differentiation|
|regulation of translation|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|nucleobase-containing compound catabolic process|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|regulation of cellular amide metabolic process|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of cell cycle phase transition|
|regulation of hemopoiesis|
|organic cyclic compound catabolic process|
|cell division|
|cellular response to growth factor stimulus|
|regulation of lymphocyte activation|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|cellular response to organic cyclic compound|
|hemopoiesis|
|response to wounding|
|negative regulation of cell cycle|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|immune system development|
|mRNA metabolic process|
|negative regulation of cell differentiation|
|regulation of cell cycle process|
|regulation of cellular catabolic process|
|response to lipid|
|cellular macromolecule catabolic process|
|response to hormone|
|response to organic cyclic compound|
|leukocyte activation|
|negative regulation of developmental process|
|protein phosphorylation|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cell activation|
|response to cytokine|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|phosphorylation|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of immune system process|
|RNA metabolic process|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.57|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.88|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.78|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.75|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.7|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.76|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.84|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nprl2|NPRL2]]|0.464|
|[[:human genes:n:nprl3|NPRL3]]|0.445|
|[[:human genes:m:msi2|MSI2]]|0.445|
|[[:human genes:d:depdc5|DEPDC5]]|0.44|
|[[:human genes:s:szt2|SZT2]]|0.433|
|[[:human genes:z:zfp36l1|ZFP36L1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10874
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFP36L2 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>