ZFX [The Human Chemical-Genetic Interaction Map Project]

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======= ZFX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFX
  * **<color #00a2e8>Official Name</color>**: zinc finger protein X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7543|7543]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17010|P17010]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/314980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable transcriptional activator.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Zfx Zfy act|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription coactivator activity|
|nucleolus|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.66|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.22|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.04|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.83|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.71|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.77|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.9|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bap1|BAP1]]|0.531|
|[[:human genes:c:cbfb|CBFB]]|0.53|
|[[:human genes:n:nsd1|NSD1]]|0.529|
|[[:human genes:m:mef2c|MEF2C]]|0.528|
|[[:human genes:m:maml1|MAML1]]|0.519|
|[[:human genes:i:id3|ID3]]|0.516|
|[[:human genes:r:rnmt|RNMT]]|0.511|
|[[:human genes:s:ssbp2|SSBP2]]|0.488|
|[[:human genes:s:sox7|SOX7]]|0.484|
|[[:human genes:f:fli1|FLI1]]|0.483|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.469|
|[[:human genes:x:xpo6|XPO6]]|0.462|
|[[:human genes:d:dohh|DOHH]]|0.46|
|[[:human genes:r:runx1|RUNX1]]|0.459|
|[[:human genes:a:asxl2|ASXL2]]|0.448|
|[[:human genes:r:rptor|RPTOR]]|0.446|
|[[:human genes:c:ccdc101|CCDC101]]|0.441|
|[[:human genes:r:rrm1|RRM1]]|0.439|
|[[:human genes:z:zbtb44|ZBTB44]]|0.43|
|[[:human genes:l:lmo2|LMO2]]|0.428|
|[[:human genes:a:alg5|ALG5]]|0.426|
|[[:human genes:g:gmppb|GMPPB]]|0.421|
|[[:human genes:l:ldb1|LDB1]]|0.421|
|[[:human genes:t:trmt10a|TRMT10A]]|0.42|
|[[:human genes:m:med23|MED23]]|0.416|
|[[:human genes:d:dhx29|DHX29]]|0.412|
|[[:human genes:s:shoc2|SHOC2]]|0.407|
|[[:human genes:s:stt3a|STT3A]]|0.405|
|[[:human genes:d:dpagt1|DPAGT1]]|0.403|
|[[:human genes:m:mtor|MTOR]]|0.402|
|[[:human genes:t:triap1|TRIAP1]]|0.401|
|[[:human genes:m:mllt1|MLLT1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/26|
|bone|0/26|
|breast|2/30|
|central nervous system|1/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4309
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFX Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>