ZMPSTE24 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ZMPSTE24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZMPSTE24
  * **<color #00a2e8>Official Name</color>**: zinc metallopeptidase STE24
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10269|10269]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75844|O75844]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZMPSTE24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZMPSTE24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M48|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H2B-K5 acetylation|
|regulation of termination of RNA polymerase I transcription|
|maintenance of rDNA|
|prenylated protein catabolic process|
|CAAX-box protein processing|
|calcium ion import into sarcoplasmic reticulum|
|DNA hypomethylation|
|hypomethylation of CpG island|
|histone H2B acetylation|
|CAAX-box protein maturation|
|histone H2A phosphorylation|
|regulation of mitotic cell cycle DNA replication|
|regulation of DNA-templated transcription, termination|
|CAMKK-AMPK signaling cascade|
|calmodulin dependent kinase signaling pathway|
|inflammatory cell apoptotic process|
|maintenance of DNA repeat elements|
|response to DNA damage checkpoint signaling|
|response to DNA integrity checkpoint signaling|
|response to cell cycle checkpoint signaling|
|regulation of histone H4-K16 acetylation|
|negative regulation of production of miRNAs involved in gene silencing by miRNA|
|metalloexopeptidase activity|
|regulation of histone H4 acetylation|
|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of gene silencing by miRNA|
|sarcoplasmic reticulum calcium ion transport|
|negative regulation of posttranscriptional gene silencing|
|negative regulation of gene silencing by RNA|
|regulation of nuclear cell cycle DNA replication|
|determination of adult lifespan|
|cardiac muscle fiber development|
|regulation of production of miRNAs involved in gene silencing by miRNA|
|regulation of production of small RNA involved in gene silencing by RNA|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|regulation of DNA methylation|
|regulation of cardiac muscle cell membrane repolarization|
|adult walking behavior|
|histone phosphorylation|
|cellular response to gamma radiation|
|walking behavior|
|regulation of transcription by RNA polymerase I|
|growth plate cartilage development|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|regulation of membrane repolarization|
|multicellular organism aging|
|negative regulation of gene silencing|
|regulation of hormone metabolic process|
|regulation of cellular senescence|
|endochondral bone growth|
|calcium ion import|
|cartilage development involved in endochondral bone morphogenesis|
|thymus development|
|bone growth|
|nuclear inner membrane|
|bone mineralization|
|regulation of cell aging|
|regulation of transcription regulatory region DNA binding|
|nuclear envelope organization|
|regulation of DNA-dependent DNA replication|
|ventricular cardiac muscle tissue development|
|response to gamma radiation|
|regulation of histone acetylation|
|muscle fiber development|
|cardiac muscle cell development|
|regulation of peptidyl-lysine acetylation|
|cardiac cell development|
|regulation of multicellular organism growth|
|cellular response to ionizing radiation|
|regulation of protein acetylation|
|hair follicle development|
|endochondral bone morphogenesis|
|skin epidermis development|
|regulation of defense response to virus|
|regulation of bone mineralization|
|hair cycle process|
|molting cycle process|
|adult locomotory behavior|
|regulation of fibroblast proliferation|
|multicellular organism growth|
|kidney morphogenesis|
|regulation of gene silencing by miRNA|
|cardiac muscle cell differentiation|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|hair cycle|
|molting cycle|
|biomineral tissue development|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|cardiac conduction|
|biomineralization|
|organ growth|
|regulation of TOR signaling|
|double-stranded DNA binding|
|metalloendopeptidase activity|
|integral component of endoplasmic reticulum membrane|
|neuromuscular process|
|regulation of DNA replication|
|bone morphogenesis|
|histone acetylation|
|regulation of glucose metabolic process|
|regulation of protein complex disassembly|
|cardiocyte differentiation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|regulation of DNA binding|
|liver development|
|cardiac ventricle development|
|hepaticobiliary system development|
|regulation of gene silencing|
|nucleus organization|
|multicellular organismal signaling|
|striated muscle cell development|
|regulation of cellular carbohydrate metabolic process|
|protein acetylation|
|adult behavior|
|regulation of histone modification|
|calcium-mediated signaling|
|muscle cell development|
|response to ionizing radiation|
|regulation of cell shape|
|protein processing|
|cardiac muscle tissue development|
|cardiac chamber development|
|cartilage development|
|cellular response to radiation|
|regulation of signal transduction by p53 class mediator|
|protein acylation|
|regulation of chromatin organization|
|regulation of ossification|
|locomotory behavior|
|bone development|
|striated muscle cell differentiation|
|regulation of carbohydrate metabolic process|
|cellular response to biotic stimulus|
|regulation of response to DNA damage stimulus|
|connective tissue development|
|protein maturation|
|regulation of stress-activated protein kinase signaling cascade|
|skeletal system morphogenesis|
|regulation of heart contraction|
|muscle cell differentiation|
|calcium ion transport|
|heart morphogenesis|
|ossification|
|kidney development|
|aging|
|striated muscle tissue development|
|renal system development|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle tissue development|
|divalent inorganic cation transport|
|peptidyl-lysine modification|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|urogenital system development|
|regulation of developmental growth|
|regulation of autophagy|
|second-messenger-mediated signaling|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|skin development|
|developmental growth|
|growth|
|regulation of lipid metabolic process|
|gland development|
|epidermis development|
|endomembrane system organization|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|response to radiation|
|regulation of immune effector process|
|muscle structure development|
|regulation of ion transmembrane transport|
|regulation of cell morphogenesis|
|skeletal system development|
|DNA repair|
|regulation of response to biotic stimulus|
|heart development|
|modification-dependent protein catabolic process|
|regulation of hormone levels|
|modification-dependent macromolecule catabolic process|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|metal ion transport|
|immune system development|
|regulation of growth|
|protein catabolic process|
|regulation of ion transport|
|chromatin organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|cation transport|
|regulation of cellular catabolic process|
|membrane organization|
|circulatory system development|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|apoptotic process|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|protein phosphorylation|
|regulation of catabolic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell death|
|regulation of response to external stimulus|
|epithelium development|
|response to abiotic stimulus|
|regulation of cell cycle|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|proteolysis|
|phosphorylation|
|regulation of organelle organization|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|ion transport|
|nervous system process|
|negative regulation of nucleobase-containing compound metabolic process|
|response to endogenous stimulus|
|regulation of response to stress|
|intracellular transport|
|regulation of cell population proliferation|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|system process|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16556
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZMPSTE24 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>