ZNF106 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF106 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF106
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 106
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64397|64397]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2Y7|Q9H2Y7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF106&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF106|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603988|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|insulin receptor signaling pathway|
|SH3 domain binding|
|cellular response to insulin stimulus|
|response to insulin|
|cellular response to peptide hormone stimulus|
|cellular response to peptide|
|response to peptide hormone|
|nuclear speck|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|enzyme linked receptor protein signaling pathway|
|nucleolus|
|response to hormone|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|RNA binding|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.34|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.95|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.85|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.72|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.72|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.76|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.82|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.89|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.91|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.95|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.99|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.555|
|[[:human genes:p:psmc1|PSMC1]]|0.531|
|[[:human genes:r:rrn3|RRN3]]|0.531|
|[[:human genes:d:dtl|DTL]]|0.53|
|[[:human genes:p:psmd1|PSMD1]]|0.529|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.529|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.525|
|[[:human genes:m:myo1h|MYO1H]]|0.525|
|[[:human genes:p:psmd3|PSMD3]]|0.517|
|[[:human genes:s:supt6h|SUPT6H]]|0.513|
|[[:human genes:c:ctr9|CTR9]]|0.511|
|[[:human genes:v:vasn|VASN]]|0.508|
|[[:human genes:c:cdc73|CDC73]]|0.501|
|[[:human genes:s:sec13|SEC13]]|0.501|
|[[:human genes:v:vps54|VPS54]]|0.501|
|[[:human genes:c:chd4|CHD4]]|0.5|
|[[:human genes:z:zfand5|ZFAND5]]|0.498|
|[[:human genes:r:rbm39|RBM39]]|0.498|
|[[:human genes:c:c14orf93|C14orf93]]|0.496|
|[[:human genes:p:psmc2|PSMC2]]|0.493|
|[[:human genes:p:psmd11|PSMD11]]|0.49|
|[[:human genes:r:rps12|RPS12]]|0.485|
|[[:human genes:t:ticrr|TICRR]]|0.484|
|[[:human genes:p:paf1|PAF1]]|0.482|
|[[:human genes:p:psma6|PSMA6]]|0.481|
|[[:human genes:p:psmc6|PSMC6]]|0.48|
|[[:human genes:f:fam160a1|FAM160A1]]|0.477|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.471|
|[[:human genes:c:copa|COPA]]|0.469|
|[[:human genes:z:znf655|ZNF655]]|0.469|
|[[:human genes:t:top1mt|TOP1MT]]|0.468|
|[[:human genes:r:rbbp5|RBBP5]]|0.468|
|[[:human genes:e:elmod3|ELMOD3]]|0.468|
|[[:human genes:o:orc1|ORC1]]|0.466|
|[[:human genes:m:myh2|MYH2]]|0.464|
|[[:human genes:r:rps2|RPS2]]|0.46|
|[[:human genes:f:fbxo5|FBXO5]]|0.459|
|[[:human genes:w:wdr43|WDR43]]|0.455|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.455|
|[[:human genes:s:smg7|SMG7]]|0.455|
|[[:human genes:n:nop16|NOP16]]|0.455|
|[[:human genes:s:s1pr4|S1PR4]]|0.455|
|[[:human genes:s:ssh2|SSH2]]|0.454|
|[[:human genes:o:ogfr|OGFR]]|0.454|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.454|
|[[:human genes:p:psmb4|PSMB4]]|0.454|
|[[:human genes:c:cdca3|CDCA3]]|0.453|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.452|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.452|
|[[:human genes:k:kif3c|KIF3C]]|0.45|
|[[:human genes:s:smg1|SMG1]]|0.448|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.448|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.447|
|[[:human genes:g:gosr2|GOSR2]]|0.446|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.446|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.446|
|[[:human genes:r:rps28|RPS28]]|0.446|
|[[:human genes:a:akirin2|AKIRIN2]]|0.445|
|[[:human genes:a:atxn1|ATXN1]]|0.445|
|[[:human genes:t:tfip11|TFIP11]]|0.444|
|[[:human genes:s:snrpa1|SNRPA1]]|0.444|
|[[:human genes:k:kpnb1|KPNB1]]|0.444|
|[[:human genes:d:ddtl|DDTL]]|0.443|
|[[:human genes:t:twistnb|TWISTNB]]|0.441|
|[[:human genes:a:aamp|AAMP]]|0.441|
|[[:human genes:s:sf3a3|SF3A3]]|0.44|
|[[:human genes:s:sf3a1|SF3A1]]|0.439|
|[[:human genes:m:myb|MYB]]|0.439|
|[[:human genes:m:mt1e|MT1E]]|0.438|
|[[:human genes:p:psap|PSAP]]|0.438|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.437|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.436|
|[[:human genes:p:pwp2|PWP2]]|0.436|
|[[:human genes:c:cbwd5|CBWD5]]|0.435|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.434|
|[[:human genes:p:pola2|POLA2]]|0.434|
|[[:human genes:n:nupl1|NUPL1]]|0.434|
|[[:human genes:p:psmd6|PSMD6]]|0.434|
|[[:human genes:t:terf2|TERF2]]|0.433|
|[[:human genes:w:wdr87|WDR87]]|0.433|
|[[:human genes:n:nol12|NOL12]]|0.432|
|[[:human genes:u:upf1|UPF1]]|0.432|
|[[:human genes:a:ankle1|ANKLE1]]|0.432|
|[[:human genes:s:stil|STIL]]|0.431|
|[[:human genes:p:pan3|PAN3]]|0.43|
|[[:human genes:c:cbwd3|CBWD3]]|0.43|
|[[:human genes:r:rad51|RAD51]]|0.429|
|[[:human genes:o:or10g3|OR10G3]]|0.429|
|[[:human genes:r:rnf4|RNF4]]|0.428|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.426|
|[[:human genes:l:lrr1|LRR1]]|0.426|
|[[:human genes:m:med12|MED12]]|0.426|
|[[:human genes:c:ccdc94|CCDC94]]|0.424|
|[[:human genes:i:igfn1|IGFN1]]|0.424|
|[[:human genes:t:tceb3c|TCEB3C]]|0.424|
|[[:human genes:r:rfxank|RFXANK]]|0.424|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.422|
|[[:human genes:d:dnm2|DNM2]]|0.422|
|[[:human genes:c:cnot1|CNOT1]]|0.421|
|[[:human genes:c:cdc6|CDC6]]|0.419|
|[[:human genes:s:scaf1|SCAF1]]|0.419|
|[[:human genes:s:supt5h|SUPT5H]]|0.419|
|[[:human genes:t:traip|TRAIP]]|0.418|
|[[:human genes:m:med17|MED17]]|0.418|
|[[:human genes:r:rrm1|RRM1]]|0.417|
|[[:human genes:c:ckap5|CKAP5]]|0.417|
|[[:human genes:u:ubap1|UBAP1]]|0.417|
|[[:human genes:n:npipb5|NPIPB5]]|0.415|
|[[:human genes:c:cgb2|CGB2]]|0.415|
|[[:human genes:c:chmp2a|CHMP2A]]|0.415|
|[[:human genes:n:nbpf16|NBPF16]]|0.414|
|[[:human genes:h:hap1|HAP1]]|0.414|
|[[:human genes:i:ints6|INTS6]]|0.413|
|[[:human genes:t:topbp1|TOPBP1]]|0.412|
|[[:human genes:s:syt9|SYT9]]|0.412|
|[[:human genes:s:sfpq|SFPQ]]|0.411|
|[[:human genes:r:ranbp2|RANBP2]]|0.411|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.411|
|[[:human genes:r:rpsa|RPSA]]|0.41|
|[[:human genes:m:mcoln1|MCOLN1]]|0.409|
|[[:human genes:z:znf830|ZNF830]]|0.409|
|[[:human genes:g:gon4l|GON4L]]|0.409|
|[[:human genes:a:aaas|AAAS]]|0.409|
|[[:human genes:f:fam86b2|FAM86B2]]|0.409|
|[[:human genes:m:myo18a|MYO18A]]|0.408|
|[[:human genes:n:nup62|NUP62]]|0.407|
|[[:human genes:p:pan2|PAN2]]|0.407|
|[[:human genes:p:prpf8|PRPF8]]|0.407|
|[[:human genes:r:rpa2|RPA2]]|0.407|
|[[:human genes:s:slc4a1|SLC4A1]]|0.407|
|[[:human genes:c:cope|COPE]]|0.407|
|[[:human genes:m:mms22l|MMS22L]]|0.406|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.406|
|[[:human genes:r:rps9|RPS9]]|0.405|
|[[:human genes:o:orc6|ORC6]]|0.405|
|[[:human genes:r:rpl30|RPL30]]|0.405|
|[[:human genes:n:nol10|NOL10]]|0.405|
|[[:human genes:c:copg1|COPG1]]|0.404|
|[[:human genes:p:psmb1|PSMB1]]|0.404|
|[[:human genes:r:rpl6|RPL6]]|0.403|
|[[:human genes:p:psmd7|PSMD7]]|0.403|
|[[:human genes:n:nbpf10|NBPF10]]|0.402|
|[[:human genes:c:ccdc73|CCDC73]]|0.401|
|[[:human genes:r:rpl14|RPL14]]|0.401|
|[[:human genes:g:gnb3|GNB3]]|0.4|
|[[:human genes:l:lad1|LAD1]]|0.4|
|[[:human genes:c:ccna2|CCNA2]]|0.4|
|[[:human genes:n:nup43|NUP43]]|0.4|
|[[:human genes:a:adrm1|ADRM1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1503
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF106 Expression in NALM6 Cells: 7.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>