ZNF259 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF259 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZPR1
  * **<color #00a2e8>Official Name</color>**: ZPR1 zinc finger
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8882|8882]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75312|O75312]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF259&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF259|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603901|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-ZPR1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pre-mRNA catabolic process|
|DNA endoreduplication|
|trophectodermal cell proliferation|
|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|
|negative regulation of motor neuron apoptotic process|
|Cajal body organization|
|regulation of motor neuron apoptotic process|
|Gemini of coiled bodies|
|inner cell mass cell proliferation|
|nuclear body organization|
|blastocyst growth|
|translation initiation factor binding|
|apoptotic process involved in development|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|positive regulation of RNA splicing|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|regulation of myelination|
|cellular response to epidermal growth factor stimulus|
|cell cycle DNA replication|
|response to epidermal growth factor|
|Cajal body|
|regulation of protein import into nucleus|
|receptor tyrosine kinase binding|
|regulation of protein import|
|positive regulation of nucleocytoplasmic transport|
|positive regulation of protein localization to nucleus|
|blastocyst development|
|regulation of nucleocytoplasmic transport|
|spinal cord development|
|regulation of protein localization to nucleus|
|G1/S transition of mitotic cell cycle|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|growth cone|
|nucleus organization|
|perikaryon|
|regulation of RNA splicing|
|negative regulation of neuron apoptotic process|
|positive regulation of intracellular protein transport|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|positive regulation of intracellular transport|
|DNA replication|
|regulation of intracellular protein transport|
|RNA catabolic process|
|positive regulation of growth|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|axon|
|regulation of neuron death|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|neuronal cell body|
|nucleobase-containing compound catabolic process|
|in utero embryonic development|
|developmental growth|
|growth|
|RNA splicing|
|axon development|
|positive regulation of protein transport|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|positive regulation of establishment of protein localization|
|microtubule cytoskeleton organization|
|mRNA processing|
|organic cyclic compound catabolic process|
|cellular response to growth factor stimulus|
|response to growth factor|
|regulation of cellular protein localization|
|cell population proliferation|
|mitotic cell cycle process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|neuron projection development|
|regulation of growth|
|microtubule-based process|
|mitotic cell cycle|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|neuron development|
|zinc ion binding|
|nucleolus|
|RNA processing|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|embryo development|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|cell cycle process|
|neuron differentiation|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|cell cycle|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.36|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.26|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.21|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.2|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-2.1|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.09|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.96|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.95|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.87|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.87|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.86|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.77|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.75|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.73|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.75|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.638|
|[[:human genes:g:gnb1l|GNB1L]]|0.525|
|[[:human genes:r:rnmt|RNMT]]|0.514|
|[[:human genes:s:srp68|SRP68]]|0.511|
|[[:human genes:n:nars|NARS]]|0.497|
|[[:human genes:t:tti2|TTI2]]|0.496|
|[[:human genes:g:gmppb|GMPPB]]|0.483|
|[[:human genes:g:gfpt1|GFPT1]]|0.472|
|[[:human genes:p:pmm2|PMM2]]|0.468|
|[[:human genes:d:dad1|DAD1]]|0.467|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.466|
|[[:human genes:e:eif4e|EIF4E]]|0.458|
|[[:human genes:s:spcs3|SPCS3]]|0.456|
|[[:human genes:v:vrk1|VRK1]]|0.45|
|[[:human genes:t:tsen54|TSEN54]]|0.449|
|[[:human genes:p:polr3b|POLR3B]]|0.444|
|[[:human genes:m:med16|MED16]]|0.444|
|[[:human genes:c:ccdc101|CCDC101]]|0.442|
|[[:human genes:t:telo2|TELO2]]|0.441|
|[[:human genes:y:yars|YARS]]|0.44|
|[[:human genes:r:rptor|RPTOR]]|0.439|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.439|
|[[:human genes:p:polr3h|POLR3H]]|0.436|
|[[:human genes:m:meaf6|MEAF6]]|0.436|
|[[:human genes:f:farsb|FARSB]]|0.436|
|[[:human genes:t:tsen2|TSEN2]]|0.436|
|[[:human genes:a:aars|AARS]]|0.435|
|[[:human genes:r:rad1|RAD1]]|0.435|
|[[:human genes:d:dpagt1|DPAGT1]]|0.434|
|[[:human genes:e:ercc2|ERCC2]]|0.433|
|[[:human genes:o:osgep|OSGEP]]|0.432|
|[[:human genes:p:pelo|PELO]]|0.431|
|[[:human genes:h:haus8|HAUS8]]|0.428|
|[[:human genes:r:rpn1|RPN1]]|0.428|
|[[:human genes:m:mars|MARS]]|0.426|
|[[:human genes:t:tti1|TTI1]]|0.426|
|[[:human genes:d:ddost|DDOST]]|0.425|
|[[:human genes:d:dhdds|DHDDS]]|0.423|
|[[:human genes:n:nsmce1|NSMCE1]]|0.423|
|[[:human genes:a:alg1|ALG1]]|0.422|
|[[:human genes:r:rtcb|RTCB]]|0.422|
|[[:human genes:e:eprs|EPRS]]|0.42|
|[[:human genes:a:alg13|ALG13]]|0.419|
|[[:human genes:t:thoc3|THOC3]]|0.417|
|[[:human genes:d:dpf2|DPF2]]|0.416|
|[[:human genes:t:tbca|TBCA]]|0.416|
|[[:human genes:d:dhps|DHPS]]|0.415|
|[[:human genes:s:seh1l|SEH1L]]|0.412|
|[[:human genes:c:cct7|CCT7]]|0.41|
|[[:human genes:s:srprb|SRPRB]]|0.41|
|[[:human genes:o:oraov1|ORAOV1]]|0.408|
|[[:human genes:w:wars|WARS]]|0.406|
|[[:human genes:g:gemin5|GEMIN5]]|0.405|
|[[:human genes:t:thg1l|THG1L]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 732/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1346
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF259 Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>