ZNF445 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF445 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF445
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 445
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=353274|353274]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P59923|P59923]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF445&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF445|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619508|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
|SCAN|
|KRAB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-3.34|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.09|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.09|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.97|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.76|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.71|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.87|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arl14ep|ARL14EP]]|0.445|
|[[:human genes:c:cbx3|CBX3]]|0.442|
|[[:human genes:t:trim28|TRIM28]]|0.434|
|[[:human genes:a:atf7ip|ATF7IP]]|0.402|
|[[:human genes:t:trip12|TRIP12]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5619
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF445 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>