ZNF688 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF688 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF688
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 688
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=146542|146542]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0C7X2|P0C7X2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF688&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF688|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KRAB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular component|
|molecular function|
|DNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.14|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.13|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.91|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.88|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.72|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.71|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.7|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.78|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.88|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.89|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.96|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.02|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.07|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.49|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5425
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF688 Expression in NALM6 Cells: 2.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>