ZNF708 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF708 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF708
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 708
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7562|7562]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17019|P17019]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF708&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF708|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
|KRAB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-2.67|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.51|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.46|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.38|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.12|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.98|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.86|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.79|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.79|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.77|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.86|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.06|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.449|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19037
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF708 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>