ZP3 [The Human Chemical-Genetic Interaction Map Project]

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======= ZP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZP3
  * **<color #00a2e8>Official Name</color>**: zona pellucida glycoprotein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7784|7784]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21754|P21754]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182889|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Zona pellucida|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of type IV hypersensitivity|
|regulation of antral ovarian follicle growth|
|positive regulation of antral ovarian follicle growth|
|regulation of type IV hypersensitivity|
|positive regulation of acrosomal vesicle exocytosis|
|structural constituent of egg coat|
|positive regulation of ovarian follicle development|
|positive regulation of female gonad development|
|egg coat formation|
|regulation of acrosomal vesicle exocytosis|
|negative regulation of binding of sperm to zona pellucida|
|regulation of binding of sperm to zona pellucida|
|acrosin binding|
|negative regulation of fertilization|
|regulation of ovarian follicle development|
|positive regulation of phosphatidylinositol biosynthetic process|
|positive regulation of hypersensitivity|
|positive regulation of acute inflammatory response to antigenic stimulus|
|regulation of phosphatidylinositol biosynthetic process|
|regulation of hypersensitivity|
|positive regulation of gonad development|
|positive regulation of phospholipid biosynthetic process|
|positive regulation of inflammatory response to antigenic stimulus|
|positive regulation of acrosome reaction|
|regulation of female gonad development|
|regulation of acute inflammatory response to antigenic stimulus|
|positive regulation of fertilization|
|positive regulation of humoral immune response|
|regulation of phospholipid biosynthetic process|
|regulation of gonad development|
|regulation of acrosome reaction|
|positive regulation of calcium ion-dependent exocytosis|
|positive regulation of interleukin-4 production|
|regulation of inflammatory response to antigenic stimulus|
|regulation of interleukin-4 production|
|regulation of fertilization|
|positive regulation of acute inflammatory response|
|receptor ligand activity|
|binding of sperm to zona pellucida|
|oocyte development|
|blastocyst formation|
|oocyte differentiation|
|regulation of calcium ion-dependent exocytosis|
|regulation of acute inflammatory response|
|positive regulation of phospholipid metabolic process|
|positive regulation of T cell mediated immunity|
|sperm-egg recognition|
|positive regulation of regulated secretory pathway|
|negative regulation of reproductive process|
|positive regulation of interferon-gamma production|
|cell-cell recognition|
|regulation of T cell mediated immunity|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|positive regulation of reproductive process|
|oogenesis|
|positive regulation of lipid biosynthetic process|
|regulation of phospholipid metabolic process|
|positive regulation of exocytosis|
|positive regulation of T cell proliferation|
|blastocyst development|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of leukocyte migration|
|female gamete generation|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|extracellular matrix structural constituent|
|positive regulation of leukocyte mediated immunity|
|regulation of humoral immune response|
|positive regulation of leukocyte proliferation|
|single fertilization|
|positive regulation of inflammatory response|
|positive regulation of lipid metabolic process|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|regulation of T cell proliferation|
|regulation of reproductive process|
|regulation of adaptive immune response|
|regulation of regulated secretory pathway|
|humoral immune response mediated by circulating immunoglobulin|
|fertilization|
|positive regulation of developmental growth|
|carbohydrate binding|
|regulation of lipid biosynthetic process|
|regulation of leukocyte migration|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|regulation of lymphocyte proliferation|
|B cell mediated immunity|
|regulation of mononuclear cell proliferation|
|negative regulation of multi-organism process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|cell recognition|
|positive regulation of cell-cell adhesion|
|germ cell development|
|positive regulation of growth|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of developmental growth|
|regulation of inflammatory response|
|humoral immune response|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of lymphocyte activation|
|collagen-containing extracellular matrix|
|in utero embryonic development|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|adaptive immune response|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|regulation of growth|
|regulation of cell adhesion|
|gamete generation|
|regulation of cytokine production|
|regulation of secretion by cell|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|positive regulation of immune response|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|embryo development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|multi-organism reproductive process|
|identical protein binding|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.7|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.07|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.86|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.74|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6077
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZP3 Expression in NALM6 Cells: 2.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>