ATP10A
Gene Information
- Official Symbol: ATP10A
- Official Name: ATPase phospholipid transporting 10A (putative)
- Aliases and Previous Symbols: N/A
- Entrez ID: 57194
- UniProt: O60312
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008].
- UniProt Summary: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11930
- Expression level (log2 read counts): -4.01
ATP10A Expression in NALM6 Cells: -4.01
