BCL2L12
Gene Information
- Official Symbol: BCL2L12
- Official Name: BCL2 like 12
- Aliases and Previous Symbols: N/A
- Entrez ID: 83596
- UniProt: Q9HB09
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| zymogen inhibition |
| inhibition of cysteine-type endopeptidase activity |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| negative regulation of cellular senescence |
| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| negative regulation of cell aging |
| regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| negative regulation of signal transduction by p53 class mediator |
| negative regulation of protein processing |
| negative regulation of protein maturation |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| regulation of cellular senescence |
| regulation of cell aging |
| p53 binding |
| regulation of protein processing |
| regulation of protein maturation |
| negative regulation of response to DNA damage stimulus |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of cysteine-type endopeptidase activity |
| negative regulation of intrinsic apoptotic signaling pathway |
| regulation of intrinsic apoptotic signaling pathway |
| regulation of signal transduction by p53 class mediator |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of response to DNA damage stimulus |
| negative regulation of apoptotic signaling pathway |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| negative regulation of proteolysis |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| negative regulation of intracellular signal transduction |
| regulation of proteolysis |
| regulation of cellular response to stress |
| negative regulation of catalytic activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| negative regulation of developmental process |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cell death |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of response to stress |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of intracellular signal transduction |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Staurosporine 0.02μM R08 exp524 | -1.87 |
| Torin1 0.08μM R02 exp82 | 1.74 |
| Menadione 5μM R06 exp292 | 1.8 |
| Vinblastine 0.002μM R01 exp60 | 1.95 |
| YM155 0.0002μM R01 exp61 | 2.31 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5961
- Expression level (log2 read counts): 5.7
Expression Distribution
BCL2L12 Expression in NALM6 Cells: 5.7
