Menadione 5μM R06 exp292 [The Human Chemical-Genetic Interaction Map Project]

Synthetic analog of vitamin K, quinone redox cycle generates ROS

Class / Subclass 1: Metabolism / Nutrient
Class / Subclass 2: Environmental Stresses / Food Additive

Compound References

PubChem Name: Menadione
Synonyms: Vitamin K3
CAS #: 58-27-5
PubChem CID: 4055
IUPAC: 2-methylnaphthalene-1,4-dione
INCHI Name: InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
INCHI Key: MJVAVZPDRWSRRC-UHFFFAOYSA-N
Molecular Weight: 172.18
Canonical SMILES: CC1=CC(=O)C2=CC=CC=C2C1=O
Isomeric SMILES: N/A
Molecular Formula: C11H8O2

Compound Supplier

Supplier Name: Sigma-Aldrich
Catalog #: M5625
Lot #: N/A

Compound Characterization

LCMS: Tr 1.21 min, m/z invisible, Lamdba max 250, 262, 336 nm

Dose Response Curve

Platform ID: Menadione
Min: -21.7794; Max: 99.2492

IC	Concentration (µM)
IC10	N/A
IC20	8.0620
IC30	8.3166
IC40	8.5312
IC50	8.7331
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 06
Dose: 5µM
Days of incubation: 8
Doublings: 5.1
Numbers of reads: 31446298

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
11/2	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
ABCC1	-5.84	<0.01
SLC7A11	-5.18	<0.01
PRDX1	-4.21	<0.01
PLEKHA2	-3.45	0.01
GCLM	-3.21	<0.01
UVSSA	-2.66	0.02
C6orf136	-2.61	0.03
SWI5	-2.56	0.05
SLC3A2	-2.55	0.10
TCF4	-2.54	0.03
FAM122A	-2.51	0.03
CNOT8	-2.51	0.03
SEPHS2	-2.46	0.04
VPS25	-2.42	0.51
ZBTB7A	-2.40	0.05
MSI2	-2.33	0.07
GIMAP7	-2.30	0.08
NFKBIZ	-2.22	0.11
LCMT1	-2.22	0.11
UBE2E1	-2.20	0.12
UBE3D	-2.18	0.12
PIGY	-2.17	0.20
PAX5	-2.17	0.30
OR5R1	-2.16	0.13
SEPHS1	-2.15	0.13
STPG1	-2.14	0.21
KIDINS220	-2.13	0.14
PLN	-2.09	0.73
QRICH1	-2.09	0.35
G6PD	-2.08	0.18
DPP8	2.00	0.40
C3orf33	2.03	0.38
NUP214	2.04	0.46
KIAA1211	2.05	0.51
RBM8A	2.05	0.42
SYNPR	2.05	0.36
GPRASP1	2.06	0.36
TVP23A	2.07	0.36
CAPZA3	2.07	0.36
SYCE2	2.08	0.40
SLC10A7	2.09	0.36
DGCR14	2.09	0.42
NPIPB11	2.13	0.44
ROPN1L	2.16	0.29
SLC22A8	2.17	0.41
CDC45	2.18	0.48
PIK3CD	2.18	0.28
ZNF320	2.21	0.40
FAM84A	2.21	0.27
RPL27A	2.21	0.52
PDHX	2.22	0.27
PSMD3	2.24	0.51
UFSP2	2.27	0.26
RPL30	2.31	0.44
TCF7L2	2.36	0.18
APAF1	2.39	0.18
MFGE8	2.57	0.18
BIRC6	2.73	0.05
RPL36A-HNRNPH2	2.76	0.46
ARRDC3	2.81	0.05

Screen	Correlation	Plot
Vincristine 0.0005μM R04 exp190	0.057	View
Nutlin-3A 1.6μM R06 exp294	0.053	View
YM155 0.001μM R08 exp432	0.052	View
UM0131023 0.05μM R05 exp248	0.051	View
Docosahexaenoic-acid 50μM R07 exp356	0.074	View
Diepoxybutane 3μM R07 exp354	0.054	View
Epigallocatechin gallate 20μM R05 exp230	0.053	View

Last modified: 2026/01/15 21:36
by 127.0.0.1