YM155 0.001μM R08 exp432
Mechanism of Action
Inhibits expression of survivin, amongst other ascribed mechanisms
- Class / Subclass 1: Gene Regulation / Transcription Inhibitor
- Class / Subclass 2: Signal Transduction / Apoptosis Activator
Technical Notes
Compound References
- PubChem Name: Sepantronium bromide
- Synonyms: Sepantronium bromide
- CAS #: 781661-94-7
- PubChem CID: 11178236
- IUPAC: 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide
- INCHI Name: InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
- INCHI Key: QBIYUDDJPRGKNJ-UHFFFAOYSA-M
- Molecular Weight: 443.3
- Canonical SMILES: CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
- Isomeric SMILES: N/A
- Molecular Formula: C20H19BrN4O3
Compound Supplier
- Supplier Name: Selleck Chemicals
- Catalog #: S1130
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M)+ Calcd for C20 H19 N4 O3 363.14572; found 363.14685
Dose Response Curve
- Platform ID: YM155
- Min: -11.6044; Max: 94.1406
| IC | Concentration (µM) |
|---|---|
| IC10 | 0.0008 |
| IC20 | 0.0010 |
| IC30 | 0.0012 |
| IC40 | 0.0015 |
| IC50 | 0.0017 |
| IC60 | 0.0019 |
| IC70 | 0.0023 |
| IC80 | 0.0027 |
| IC90 | 0.0036 |
Screen Summary
- Round: 08
- Dose: 1nM
- Days of incubation: 8
- Doublings: 6.2
- Numbers of reads: 15030053
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 6/2 | Scores |
YM155 0.001μM R08 exp432
Menadione 5μM R06 exp292 vs YM155 0.001μM R08 exp432
