PDP2

Entrez Summary: This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2016].
UniProt Summary: Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

[pyruvate dehydrogenase (lipoamide)] phosphatase activity
positive regulation of pyruvate dehydrogenase activity
regulation of pyruvate dehydrogenase activity
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of acyl-CoA biosynthetic process
regulation of coenzyme metabolic process
regulation of sulfur metabolic process
magnesium-dependent protein serine/threonine phosphatase activity
regulation of cofactor metabolic process
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
positive regulation of oxidoreductase activity
protein serine/threonine phosphatase activity
regulation of fatty acid metabolic process
regulation of oxidoreductase activity
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of cellular ketone metabolic process
protein dephosphorylation
dephosphorylation
mitochondrial matrix
regulation of lipid metabolic process
regulation of cellular amide metabolic process
regulation of small molecule metabolic process
mitochondrion
positive regulation of catalytic activity
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process