Nifuroxazide 1μM R01 exp51
Mechanism of Action
Nitrofuran antibiotic
- Class / Subclass 1: Infectious Disease / Antibiotic
Technical Notes
Compound References
- PubChem Name: Nifuroxazide
- Synonyms: N/A
- CAS #: 965-52-6
- PubChem CID: 5337997
- IUPAC: 4-hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]benzamide
- INCHI Name: InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
- INCHI Key: YCWSUKQGVSGXJO-NTUHNPAUSA-N
- Molecular Weight: 275.22
- Canonical SMILES: C1=CC(=CC=C1C(=O)NN=CC2=CC=C(O2)[N+](=O)[O-])O
- Isomeric SMILES: C1=CC(=CC=C1C(=O)N/N=C/C2=CC=C(O2)[N+](=O)[O-])O
- Molecular Formula: C12H9N3O5
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: 481984
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C12H9N3O5 276.0615; found 276.0611
Dose Response Curve
- Platform ID: NAZ
- Min: -7.3989; Max: 98.6617
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 3.0271 |
| IC30 | 5.0046 |
| IC40 | 7.5570 |
| IC50 | 11.0306 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 01
- Dose: 1µM
- Days of incubation: 8
- Doublings: 6.8
- Numbers of reads: 10600757
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Nifuroxazide 1μM R01 exp51
NFN1 0.1μM R01 exp49 vs Nifuroxazide 1μM R01 exp51
