FREM3

Entrez Summary: This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The protein belongs to the family of FRAS1/FREM extracellular matrix proteins and may play a role cell adhesion. [provided by RefSeq, Feb 2017].
UniProt Summary: Extracellular matrix protein which may play a role in cell adhesion. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 1μM R01 exp51	-2.32
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.03
Mitomycin-C 0.06μM R08 exp503	-1.87
Thimerosal 0.85μM R08 exp529	-1.86
CR131-b 0.005μM R08 exp474	-1.74
Resveratrol 16μM R03 exp147	-1.73
Cyclosporin-A 0.8μM R07 exp347	1.83
GSK-J4 1μM R07 exp362	2.26

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

basement membrane
collagen-containing extracellular matrix
cell adhesion
biological adhesion
extracellular space