Resveratrol 16μM R03 exp147
Mechanism of Action
Putative sirtuin activator, many other ascribed activities, analog of pterostilbene
- Class / Subclass 1: Gene Regulation / Epigenetic Activator
Technical Notes
Compound References
- PubChem Name: Resveratrol
- Synonyms: SRT 501; trans-Resveratrol
- CAS #: 501-36-0
- PubChem CID: 445154
- IUPAC: 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
- INCHI Name: InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
- INCHI Key: LUKBXSAWLPMMSZ-OWOJBTEDSA-N
- Molecular Weight: 228.24
- Canonical SMILES: C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
- Isomeric SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O
- Molecular Formula: C14H12O3
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: R150000
- Lot #: 2-ZNL-10-1
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C14H12O3 229.08592; found 229.086
Dose Response Curve
- Platform ID: RESVERATROL
- Min: 2.6734; Max: 95.8148
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 9.7877 |
| IC30 | 14.8061 |
| IC40 | 20.7871 |
| IC50 | 28.3805 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 16µM
- Days of incubation: 8
- Doublings: 4.8
- Numbers of reads: 12942673
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 12/4 | Scores |