KDSR

Gene Information

Official Symbol: KDSR
Official Name: 3-ketodihydrosphingosine reductase
Aliases and Previous Symbols: N/A
Entrez ID: 2531
UniProt: Q06136
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). {ECO:0000269|PubMed:28575652}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SB203580 25μM R03 exp149	-4.78
BH1 1μM R04 exp169	-4.68
GSK343 3μM R03 exp124	-4.49
B02 10μM R08 exp453	-4.32
GSK591 2.6μM R03 exp128	-3.84
SB202190 10μM R03 exp148	-3.66
BRD2 inhibitor II 20μM R07 exp341	-3.62
Q15 1 to 2μM on day4 R04 exp164	-3.6
ZLN024 50μM R08 exp538	-3.59
UM0011500 5μM R05 exp245	-3.57
Bortezomib 0.005μM R00 exp6	-3.54
GW501516 25μM R06 exp285	-3.47
Tubacin 1.6μM R07 exp416	-3.47
Asunaprenir 3μM R07 exp336	-3.42
UM0011500 10μM R05 exp246	-3.38
IU1-47 25μM R04 exp182	-3.37
Vemurafenib 6.6μM R08 exp434	-3.33
proTAME 5μM R04 exp187	-3.27
CCT251545 20μM R07 exp326	-3.24
L-74142 5μM R03 exp131	-3.17
Momordin-Ic 10μM R08 exp506	-3.17
BS-181 20μM R08 exp461	-3.13
Cincreasin 100μM R08 exp473	-3.07
Vemurafenib 6.6μM R02 exp89	-3.07
Nicotinamide 2000μM R01 exp50	-3.04
UNC1999 2μM R03 exp155	-2.98
Trametinib 10μM R02 exp83	-2.84
Lead acetate 990μM R08 exp496	-2.84
L-BMAA 500 to 750μM on day4 R04 exp185	-2.77
Nicotine 3000μM R08 exp510	-2.72
All-trans-Retinoic-Acid 40μM R07 exp334	-2.7
Lead acetate 2000μM R08 exp498 no dilution day6	-2.65
Ribavirin 10 to 15μM on day4 R04 exp160	-2.65
Caffeine 2600μM R08 exp463	-2.61
SGC0946 7μM R03 exp151	-2.61
HMS-I2 5μM R06 exp287	-2.6
RO-3306 3 to 4μM on day4 R04 exp165	-2.59
Clomiphene 4.4μM R02 exp68	-2.58
Resveratrol 16μM R03 exp147	-2.55
UNC2400 2μM R03 exp156	-2.54
Bisphenol F 50μM R08 exp457	-2.51
Golgicide-A 2μM R03 exp121	-2.47
Cyclosporin-A 3μM R07 exp348	-2.46
Bafilomycin-A1 0.009μM R08 exp454	-2.39
Golgicide-A 4μM R03 exp122	-2.35
Wiskostatin 3μM R07 exp422	-2.35
IU1-C 25μM R04 exp183	-2.34
NFN1 1μM R03 exp100	-2.33
PT-1 25μM R07 exp392	-2.33
LJH685 50μM R08 exp433	-2.3
Selumetinib 20μM R02 exp81	-2.29
Nicotinamide 1000μM R03 exp101	-2.25
PF-06409577 20μM R07 exp389	-2.21
NN-Diethyl-meta-toluamide 500μM R08 exp438	-2.19
LJH685 5μM R02 exp73	-2.19
Mdivi-1 15μM R05 exp217	-2.19
NN-Diethyl-meta-toluamide 100μM R05 exp237	-2.18
Pomalidomide 20μM R07 exp391	-2.18
NFN1 0.4μM R03 exp99	-2.16
MKC9989 10μM R03 exp133	-2.15
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-2.14
Cannabidiol 13μM R08 exp465	-2.14
Prochlorperazine 5.2μM R02 exp77	-2.14
Apcin 25μM plus proTAME 2μM R04 exp177	-2.13
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.11
GSK-J5 1.5μM R08 exp484	-2.1
Nocodazole 0.02μM R00 exp23	-2.09
LLY-284 2.6μM R06 exp291	-2.06
Lapatinib 5μM R01 exp47	-2.05
Epigallocatechin gallate 20μM R05 exp230	-2.01
PNU96415E 10μM R03 exp145	-1.99
Curcumin 6.5μM R06 exp277	-1.97
A-395N 10μM R05 exp219	-1.91
Daidzin 10μM R06 exp280	-1.88
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.83
WYE-354 6μM R02 exp90	-1.77
Chlorpromazine 10μM R07 exp344	-1.75
Cyclosporin-A 0.8μM R07 exp347	-1.75
BI-2536 0.0042μM R03 exp95	-1.73
CHIR-124 0.04μM R06 exp272	-1.72
Isoniazid 100μM R08 exp494	-1.72
Lenalidomide 20μM R07 exp375	-1.72
TRAIL 5ng/ml R00 exp35	-1.72
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.71
Myriocin 25μM R06 exp293	1.72
Atovaquone 15μM R08 exp451	1.74
Aphidicolin 0.4μM R08 exp440	1.75
Thimerosal 0.85μM R08 exp529	1.8
AICAR 240μM R05 exp211	1.82
Phenformin 20μM R05 exp212	1.85
Staurosporine 0.02μM R08 exp524	1.85
Trientine 500μM R08 exp534	1.85
GSK626616 14μM R08 exp485	1.9
Mitomycin-C 0.06μM R08 exp503	1.96
AICAR 240μM R03 exp116	1.97
Artemisinin 50μM R08 exp450	2
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.03
Mubritinib 0.2μM R01 exp48	2.05
Milciclib 2μM R08 exp502	2.13
CI-1040 9.5μM R08 exp472	2.14
QNZ 0.01μM R08 exp439	2.21
Bleomycin 5μM R08 exp459	2.27
Phenformin 20μM R03 exp143	2.28
MS023 2μM R03 exp134	2.3
Doxorubicin 0.02μM R08 exp478	2.31
MS023 7μM R03 exp135	4.45

Gene	Correlation
THG1L	0.609
DHRSX	0.588
DOHH	0.577
FAF2	0.558
ROMO1	0.557
DOLK	0.548
PLAA	0.542
TRIAP1	0.529
TRMT61A	0.524
ELP3	0.524
PGM3	0.522
CEPT1	0.52
SSB	0.52
ALG1	0.515
GFPT1	0.507
PPA2	0.505
RPTOR	0.503
VEZT	0.502
UBE2G2	0.5
DNLZ	0.499
SRP14	0.498
APAF1	0.497
SEC62	0.497
ALG6	0.495
MBTPS1	0.495
BAK1	0.494
MOCS3	0.493
FLVCR1	0.493
CTDNEP1	0.488
ATP5O	0.479
UAP1	0.477
DPAGT1	0.477
ENY2	0.475
TRMT10A	0.475
GTF3C6	0.474
ELP2	0.473
RNMT	0.472
SERF2	0.472
KIAA0391	0.471
SLC25A26	0.471
SRD5A3	0.471
YARS2	0.469
GTF3C4	0.468
ATIC	0.467
ATP2A2	0.466
ATP5J	0.465
NSD1	0.463
RFT1	0.458
URM1	0.458
BCS1L	0.456
PIK3R4	0.453
ATP5A1	0.453
FH	0.451
HCCS	0.45
CASP9	0.45
PIK3C3	0.449
PMM2	0.449
CHKA	0.448
N6AMT1	0.447
GMPPB	0.445
ATXN10	0.445
TAMM41	0.443
MLST8	0.442
VDAC2	0.44
ATP5B	0.44
DARS2	0.439
EXOC4	0.438
ALG13	0.435
MBTPS2	0.435
PDAP1	0.434
UBQLN1	0.434
ELP6	0.433
TIMM22	0.431
ATP5I	0.43
LSM10	0.43
SRRD	0.43
CRLS1	0.428
CBFB	0.427
DR1	0.427
ALG5	0.427
C10orf2	0.425
BAP1	0.424
TEN1	0.423
ATP5D	0.423
VPS41	0.422
PPCDC	0.422
PARS2	0.422
CTU1	0.422
TSEN54	0.421
MARCH5	0.421
PTDSS1	0.42
PMVK	0.418
TEFM	0.418
RPIA	0.417
DUSP12	0.417
HSPD1	0.416
CYCS	0.415
RPP21	0.414
MRPS14	0.414
FECH	0.413
PGS1	0.413
ZZZ3	0.413
BPTF	0.413
NCOR1	0.412
MTOR	0.411
KIAA1432	0.41
SPR	0.41
SUPV3L1	0.41
MRPL21	0.41
CHCHD4	0.409
ALG9	0.409
MAPKAP1	0.408
ATP5L	0.408
TRNT1	0.408
CNEP1R1	0.407
HSD17B10	0.407
H2AFZ	0.404
WDR24	0.401
TAZ	0.401
DPH5	0.4

Global Fraction of Cell Lines Where Essential: 33/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	9/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	0/20
lung	4/75
lymphocyte	2/16
ovary	0/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 7669
Expression level (log2 read counts): 5.58

Expression Distribution

KR
adh short

3-dehydrosphinganine reductase activity
3-keto-sphinganine metabolic process
sphingoid metabolic process
cellular ketone metabolic process
sphingolipid biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
ammonium ion metabolic process
membrane lipid metabolic process
lipid biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
oxidation-reduction process
endoplasmic reticulum
lipid metabolic process
organonitrogen compound biosynthetic process
extracellular space
small molecule metabolic process
membrane