IU1-C 25μM R04 exp183
Mechanism of Action
Inactive analog of IU1-47
- Class / Subclass 1: Proteostasis / Ubiquitin-Proteasome Inhibitor
Technical Notes
Compound References
- PubChem Name: [1-(4-Fluorophenyl)-2,5-dimethylpyrrol-3-yl]-(4-methylpiperidin-1-yl)methanone
- Synonyms: N/A
- CAS #: 853725-21-0
- PubChem CID: 4791181
- IUPAC: [1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-(4-methylpiperidin-1-yl)methanone
- INCHI Name: InChI=1S/C19H23FN2O/c1-13-8-10-21(11-9-13)19(23)18-12-14(2)22(15(18)3)17-6-4-16(20)5-7-17/h4-7,12-13H,8-11H2,1-3H3
- INCHI Key: RBDWITRZTOAEIG-UHFFFAOYSA-N
- Molecular Weight: 314.4
- Canonical SMILES: CC1CCN(CC1)C(=O)C2=C(N(C(=C2)C)C3=CC=C(C=C3)F)C
- Isomeric SMILES: N/A
- Molecular Formula: C19H23FN2O
Compound Supplier
- Supplier Name: In house - Harvard Medical School - Daniel Finley group - Synthesized as described in Lee and al., 2010
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C19H23FN2O 315.18672; found 315.18712
Dose Response Curve
- Platform ID: IU1-C
- Min: -17.6616; Max: 19.0561
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 04
- Dose: 25µM
- Days of incubation: 8
- Doublings: 4.9
- Numbers of reads: 12555462
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 3/7 | Scores |
IU1-C 25μM R04 exp183
IU1-C 25μM R04 exp183 vs UMK57 0.6μM R03 exp107
Citral 50μM R06 exp274 vs IU1-C 25μM R04 exp183
FK-506 5μM R07 exp358 vs IU1-C 25μM R04 exp183
