ZCRB1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.77
Demecolcine 0.03μM R05 exp228	-2.63
BI-2536 0.001μM R01 exp41	-2.61
VHL-ligand-1 20μM R07 exp421	-2.61
NFN1 0.1μM R01 exp49	-2.44
GSK-J4 1μM R07 exp362	-2.35
Nicotinate 1000μM R03 exp140	-2.35
UM131593 0.1μM R01 exp58	-2.25
GSK461364A 0.005μM R03 exp125	-2.23
MLN-4924 0.2μM R00 exp21	-2.22
Cycloheximide 0.02μM R00 exp14	-2.04
A-769662 20μM R07 exp331	-2
Vinblastine 0.002μM R01 exp60	-2
Nicotinamide 2000μM R01 exp50	-1.99
2-Methoxyestradiol 0.2μM R01 exp40	-1.98
IU1-C 25μM R04 exp183	-1.98
Alpha-Amanitin 0.5μM R00 exp5	-1.97
BI-6727 0.001μM R01 exp42	-1.97
LJH685 5μM R02 exp73	-1.97
3-Bromopyruvate 7μM R04 exp175	-1.96
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.95
YM155 0.0002μM R01 exp61	-1.92
Docetaxel 0.002μM R01 exp45	-1.91
Ribavirin 10μM R01 exp52	-1.9
Rifampicin 10μM R00 exp32	-1.9
BI-2536 0.0042μM R03 exp95	-1.79
CCCP 0.1μM R00 exp10	-1.77
Taxol 0.002μM R01 exp54	-1.77
LY2090314 0.003μM R08 exp500 no dilution day6	-1.75
Lenalidomide 20μM R07 exp375	-1.71
Geldanamycin 0.01μM R05 exp235	-1.7
Staurosporine 0.02μM R08 exp524	1.72
Lead acetate 2000μM R08 exp497	1.79
Vemurafenib 6.6μM R02 exp89	1.87
Amiloride 100μM R08 exp447	2.01
2-Deoxy-D-glucose 800μM R05 exp214	2.04
Cannabidiol 20μM R08 exp466	2.46
iCRT14 30μM R08 exp492	2.61
UM0129480 7μM R02 exp85	2.67
Vemurafenib 6.6μM R08 exp434	2.69
Q15 2.7μM R02 exp79	2.7

Global Fraction of Cell Lines Where Essential: 195/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	9/28
bone	5/26
breast	5/33
central nervous system	20/56
cervix	1/4
colorectal	1/17
esophagus	5/13
fibroblast	1/1
gastric	3/16
kidney	1/21
liver	6/20
lung	23/75
lymphocyte	5/16
ovary	6/26
pancreas	8/24
peripheral nervous system	6/16
plasma cell	5/15
prostate	0/1
skin	9/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	13/29
uterus	1/5

Expression Distribution

U12-type spliceosomal complex
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
mRNA metabolic process
zinc ion binding
RNA processing
RNA binding
RNA metabolic process
gene expression