DARS2

Gene Information

Official Symbol: DARS2
Official Name: aspartyl-tRNA synthetase 2, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 55157
UniProt: Q6PI48
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rifampicin 30μM R08 exp430	-2.9
Fas-L 44ng/ml R08 exp482	-2.75
ABT-702 0.1μM R06 exp260	-2.53
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.22
ETC-159 50μM R08 exp480	-2.22
IWR1 50μM R08 exp495	-2.13
HMS-I2 5μM R06 exp287	-2.1
Colchicine 0.009μM R05 exp215	-2.08
BS-181 20μM R08 exp461	-2.05
CVT-10216 0.1μM R06 exp278	-2.02
2-Methoxyestradiol 0.2μM R01 exp40	-1.84
RS-1 10μM R08 exp519	-1.79
BI-2536 0.001μM R01 exp41	-1.77
5-Fluorouracil 2μM R00 exp1	-1.74
ABT-702 5μM R06 exp261	-1.74
MKC9989 10μM R03 exp133	-1.72
B02 10μM R08 exp453	-1.7
BI-D1870 3.15μM R02 exp66	1.7
CFI-400945 25μM R08 exp469	1.7
Hippuristanol 0.12μM R08 exp488	1.78
UM131593 0.2μM R03 exp106	1.79
Vemurafenib 6.6μM R02 exp89	1.8
Sulforaphane 9μM R08 exp525	1.8
R-DABN 8μM R03 exp111	1.81
UM0129480 7μM R02 exp85	1.83
DABN racemic mixture R03 exp93	1.85
Oligomycin-A 2μM R00 exp25	2.1
MK2206 4μM R08 exp504	2.17
KU-0063794 3.8μM R02 exp71	2.18
Calcium Ionophore 0.4μM R07 exp342	2.19
Pterostilbene 16μM R02 exp78	2.25
Pimelic-diphenylamide-106 5μM R00 exp28	2.26
LLY-283 2.6μM R06 exp290	2.31
TIC10 10μM R08 exp532	2.42
QNZ 0.01μM R08 exp439	2.44
Mubritinib 0.2μM R02 exp65	2.46
Salinomycin 3.5μM R08 exp521	2.46
Tanespimycin 14μM R08 exp527	2.52
Hydroxyurea 100μM R07 exp329	2.63
UM0125461 0.74μM R02 exp84	2.72
AICAR 240μM R03 exp116	2.75
PU-H71 1μM R08 exp515	2.95
Thimerosal 0.85μM R08 exp529	3.18
GSK-J4 1.5μM R08 exp441	3.2

Gene	Correlation
HSD17B10	0.783
MRPS14	0.726
GFM1	0.714
BCS1L	0.712
MRPL21	0.695
DAP3	0.694
MRP63	0.688
NARS2	0.685
MRPS26	0.684
MRPS16	0.682
YARS2	0.679
SCO2	0.668
COX16	0.667
QRSL1	0.666
VARS2	0.661
MRPS5	0.659
MRPS34	0.658
TARS2	0.652
MRPS6	0.643
RARS2	0.641
COA3	0.641
PARS2	0.639
MRPS21	0.638
RPUSD4	0.633
LARS2	0.633
SELRC1	0.632
C10orf2	0.63
MRPL23	0.63
FARS2	0.629
GFM2	0.626
MRPL47	0.622
MRPL53	0.621
SUPV3L1	0.621
MARS2	0.619
EARS2	0.615
TEFM	0.614
MRPS2	0.609
KIAA0391	0.608
WBSCR16	0.605
SLC25A26	0.598
TUFM	0.598
SARS2	0.594
HARS2	0.592
MRPS18A	0.589
NDUFA3	0.586
MRPS33	0.583
NDUFB11	0.582
FTSJ2	0.582
COX7B	0.581
MRPS9	0.579
MRPL45	0.577
NDUFAF7	0.574
COX17	0.572
UQCRC2	0.571
RBFA	0.571
MRPS25	0.57
PNPT1	0.57
GTPBP10	0.57
NDUFA1	0.57
AARS2	0.569
FASTKD5	0.567
MRPL20	0.566
MRPS12	0.565
ATP5D	0.56
C12orf65	0.558
RPUSD3	0.557
GATC	0.554
AIFM1	0.553
MRPL15	0.551
MRPL3	0.551
CARS2	0.55
TRUB2	0.55
PGM3	0.546
MRPS24	0.544
PET117	0.543
PET112	0.542
POLRMT	0.542
FH	0.541
RNASEH1	0.54
MRPL42	0.534
ATP5B	0.529
POLG	0.527
MRPS23	0.526
ELAC2	0.526
ATP5J	0.525
MTRF1L	0.524
RTN4IP1	0.523
COX11	0.522
NDUFC2	0.522
COX15	0.521
DHRSX	0.519
MRPL39	0.519
MRPL33	0.515
MRPL18	0.514
LSM10	0.514
ATP5A1	0.514
DNLZ	0.514
MRPS11	0.512
MRPL43	0.51
TFAM	0.509
ATP5C1	0.508
PDSS1	0.506
MRPL12	0.505
NDUFAF4	0.504
MRPL44	0.504
MTPAP	0.503
MRPL17	0.502
COA6	0.497
ATP5SL	0.495
MTG2	0.493
NDUFB6	0.493
AASDHPPT	0.493
TRIAP1	0.493
NDUFV1	0.493
NFU1	0.492
MRPL55	0.492
HCCS	0.491
VEZT	0.49
TOMM20	0.489
NDUFB5	0.489
COX6C	0.489
ATIC	0.486
NDUFA2	0.485
CHCHD4	0.485
COA5	0.484
MRPL11	0.483
NDUFAF3	0.481
MRPL52	0.481
UQCR10	0.48
POLG2	0.48
MRPS7	0.479
TFB1M	0.479
METTL17	0.479
MTERFD1	0.478
COX5A	0.477
THG1L	0.477
ATP5O	0.476
ATXN10	0.475
DOLK	0.475
WARS2	0.475
RPIA	0.473
MRPL36	0.473
C17orf89	0.473
MRPS22	0.473
TRMT61A	0.472
DPAGT1	0.472
PPCS	0.472
GTPBP8	0.471
TMEM242	0.468
MRPL4	0.468
MRPL22	0.466
MALSU1	0.465
MRPL32	0.464
SSB	0.464
MRPL34	0.462
SDHA	0.462
COX6B1	0.46
MTERFD2	0.459
PPA2	0.459
ALG6	0.457
TRMT10C	0.456
MRPS10	0.456
NDUFS2	0.455
ATP5H	0.455
NDUFB9	0.455
SRD5A3	0.449
MRPS27	0.447
MRPL41	0.446
RNMTL1	0.445
SLC25A19	0.445
PMM2	0.444
NDUFB3	0.444
DDX28	0.442
TOMM22	0.441
RFT1	0.441
TIMMDC1	0.439
KDSR	0.439
COX19	0.438
ATP5L	0.437
NDUFB1	0.436
ALG1	0.435
CRLS1	0.435
COQ4	0.434
MRPS17	0.434
MRPL27	0.433
UQCRQ	0.43
ATP5F1	0.43
IBA57	0.43
HIGD2A	0.429
SLC25A52	0.429
OPA1	0.429
DHX30	0.428
DOHH	0.428
SLC25A3	0.428
MTIF3	0.428
CYCS	0.428
ROMO1	0.427
TAMM41	0.426
MRPL28	0.426
NDUFS7	0.425
TRNT1	0.425
TAZ	0.425
MRPL35	0.424
PET100	0.424
TPK1	0.424
SCO1	0.423
MIPEP	0.421
TRMT10A	0.421
CHCHD1	0.42
COX20	0.42
HMGXB3	0.418
NDUFAF5	0.418
MTG1	0.418
TOMM40	0.418
CLPP	0.417
ALG8	0.416
ECSIT	0.416
NDUFA11	0.416
NDUFS5	0.416
COQ6	0.414
ZRSR2	0.413
ALDH18A1	0.411
MRPS18B	0.41
ACAD9	0.409
RFK	0.409
SSBP1	0.409
PTCD3	0.409
ZCRB1	0.408
MRPS35	0.407
MRPL49	0.406
ENY2	0.405
TIMM8B	0.405
MRPL13	0.405
COQ2	0.404
UAP1	0.404
MRPL37	0.404
GRSF1	0.404
ATP5E	0.403
MRPL9	0.402
UHRF1	0.401

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 42
Expression level (log2 read counts): 5.98

Expression Distribution

GAD
tRNA anti
tRNA-synt 2

mitochondrial asparaginyl-tRNA aminoacylation
aspartate-tRNA(Asn) ligase activity
aspartate-tRNA ligase activity
asparaginyl-tRNA aminoacylation
tRNA aminoacylation for mitochondrial protein translation
mitochondrial RNA metabolic process
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
tRNA binding
mitochondrial translation
mitochondrial gene expression
tRNA metabolic process
cellular amino acid metabolic process
mitochondrial matrix
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
protein homodimerization activity
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression