NDUFC2

Gene Information

Official Symbol: NDUFC2
Official Name: N/ADH:ubiquinone oxidoreductase subunit C2
Aliases and Previous Symbols: N/A
Entrez ID: 4718
UniProt: O95298
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cytochalasin-B 5μM R07 exp349	-2.08
AICAR 240μM R05 exp211	1.72
Trientine 500μM R08 exp534	1.82
5-Fluorouracil 2μM R00 exp1	1.83
Hinokiflavone 12μM R08 exp487	1.84
iCRT14 30μM R08 exp492	1.86
Ribavirin 10 to 15μM on day4 R04 exp160	1.87
Mitomycin-C 0.06μM R08 exp503	1.88
Artemisinin 50μM R08 exp450	1.95
Trimetrexate 0.03μM R08 exp535	1.96
Atovaquone 15μM R08 exp451	1.98
TIC10 10μM R08 exp532	1.98
Vemurafenib 6.6μM R08 exp434	2.09
MK-1775 0.32μM R02 exp75	2.18
Thimerosal 0.85μM R08 exp529	2.23
UM0125461 0.74μM R02 exp84	2.27
Hydroxyurea 100μM R07 exp329	2.47
Chloramphenicol 20μM R00 exp13	2.69
HMS-I2 10μM R06 exp288	2.9
Oligomycin-A 2μM R00 exp25	3.6

Gene	Correlation
NDUFA1	0.718
NDUFA3	0.695
NDUFAF7	0.668
NDUFA11	0.665
RTN4IP1	0.661
NDUFA2	0.659
NDUFS2	0.648
NDUFB9	0.647
NDUFB11	0.642
MTRF1L	0.63
ACAD9	0.629
NUBPL	0.622
TIMMDC1	0.62
NDUFB5	0.618
NDUFB7	0.615
LARS2	0.605
WBSCR16	0.602
NDUFAF3	0.6
MRPS21	0.6
MRPL45	0.599
NDUFB4	0.592
NDUFA13	0.589
NDUFAF1	0.588
NDUFC1	0.587
GRSF1	0.584
MRPL21	0.582
GFM1	0.582
MTO1	0.576
NDUFAF4	0.574
NDUFV1	0.562
NDUFS7	0.562
NDUFAF6	0.562
HSD17B10	0.562
GFM2	0.561
HMGXB3	0.56
MRP63	0.56
ATP5SL	0.557
C12orf65	0.555
NDUFA5	0.554
GTPBP10	0.554
NARS2	0.553
NDUFAF5	0.553
NDUFS5	0.552
ECSIT	0.552
DAP3	0.547
TFB1M	0.545
TMEM261	0.543
YARS2	0.542
CHCHD1	0.542
NDUFB6	0.541
NDUFS3	0.539
FTSJ2	0.538
COQ7	0.537
COX16	0.537
MRPL47	0.536
MRPS6	0.536
C17orf89	0.533
C10orf2	0.531
POLG2	0.53
COQ2	0.529
QRSL1	0.526
MTIF2	0.524
MRPS16	0.522
DARS2	0.522
NDUFA8	0.521
RPUSD3	0.52
CARS2	0.519
MRPL23	0.516
MRPL44	0.514
MTERFD1	0.513
NDUFA6	0.513
MRPS26	0.512
NDUFB2	0.511
NDUFB3	0.511
MRPS25	0.509
NDUFS1	0.509
MRPS10	0.508
MRPS34	0.506
NDUFA10	0.506
RPUSD4	0.506
NDUFS8	0.504
MRPS33	0.503
FASTKD2	0.503
PNPT1	0.502
RBFA	0.502
TEFM	0.497
SELRC1	0.497
MRPL13	0.496
ATP5C1	0.494
MRPL15	0.493
NDUFB8	0.493
SUPV3L1	0.49
MRPL3	0.49
SSBP1	0.489
TARS2	0.489
MTG1	0.488
RNASEH1	0.488
MRPS14	0.487
RARS2	0.486
MRPL43	0.485
NDUFV2	0.483
NDUFB10	0.482
MTG2	0.482
PET112	0.481
ATP5D	0.479
AIFM1	0.478
PARS2	0.477
HARS2	0.476
MRPS23	0.476
COQ4	0.475
CLPP	0.475
PET117	0.473
BCS1L	0.473
MRPS5	0.472
PDSS1	0.472
MRPL53	0.471
NFU1	0.47
TRUB2	0.47
NDUFA9	0.469
DDX28	0.468
VARS2	0.467
RNMTL1	0.466
MRPL20	0.465
METTL17	0.465
SCO2	0.465
TUFM	0.463
EARS2	0.457
AARS2	0.457
MRPL12	0.456
SLC25A3	0.455
MRPS9	0.455
FOXRED1	0.454
GTPBP6	0.453
PTCD3	0.453
FASTKD5	0.452
ATP5A1	0.451
MALSU1	0.449
MRPS35	0.448
MRPL17	0.448
MRPL41	0.447
MTPAP	0.446
MRPS18A	0.445
WARS2	0.445
KIAA0391	0.443
GATC	0.443
POLRMT	0.442
MRPL42	0.441
MRPS22	0.441
GLRX5	0.44
COX7B	0.44
SLC25A26	0.44
DHX30	0.439
COA3	0.437
ERAL1	0.437
MRPS7	0.437
IBA57	0.437
ISCA2	0.435
ATP5B	0.434
MRPL55	0.432
MRPS12	0.432
MARS2	0.432
POLG	0.429
SLC25A51	0.429
SLC25A52	0.427
MRPS18B	0.426
COX20	0.426
SARS2	0.423
TFAM	0.423
ATP5E	0.423
MRPL1	0.421
FARS2	0.419
GTPBP8	0.416
MRPL46	0.416
C1QBP	0.415
ICT1	0.414
MIPEP	0.412
COX15	0.41
ATP5H	0.409
MTIF3	0.409
COX6B1	0.408
MRPS24	0.408
MTERFD2	0.408
COA6	0.407
TOMM20	0.406
MRPS28	0.405
MRPL33	0.404
MRPS27	0.404
TIMM21	0.404
UQCRC2	0.401
ALAS1	0.401
MRPL22	0.401
MRPL35	0.4
COX19	0.4

Global Fraction of Cell Lines Where Essential: 22/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	0/26
breast	3/33
central nervous system	1/56
cervix	1/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1284
Expression level (log2 read counts): 5.37

Expression Distribution

NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I
azurophil granule membrane
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
oxidative phosphorylation
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
generation of precursor metabolites and energy
mitochondrion organization
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
cellular protein-containing complex assembly
leukocyte activation
oxidation-reduction process
secretion by cell
export from cell
cell activation
immune effector process
secretion