NDUFAF6

Entrez Summary: This gene encodes a protein that localizes to mitochondria and contains a predicted phytoene synthase domain. The encoded protein plays an important role in the assembly of complex I (NADH-ubiquinone oxidoreductase) of the mitochondrial respiratory chain through regulation of subunit ND1 biogenesis. Mutations in this gene are associated with complex I enzymatic deficiency. [provided by RefSeq, Nov 2011].
UniProt Summary: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1. {ECO:0000269|PubMed:18614015, ECO:0000269|PubMed:22019594}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	1.7
PU-H71 1μM R08 exp515	1.72
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.75
UM0129480 7μM R02 exp85	1.79
Epothilone-B 0.0015μM R05 exp231	1.8
Thimerosal 0.85μM R08 exp529	1.81
Ribavirin 10 to 15μM on day4 R04 exp160	1.82
Mubritinib 0.2μM R02 exp65	1.83
Trientine 500μM R08 exp534	1.86
Chloramphenicol 20μM R00 exp13	1.88
Vemurafenib 6.6μM R08 exp434	1.94
Tanespimycin 14μM R08 exp527	1.97
Azithromycin 100μM R08 exp452	2
Trimetrexate 0.03μM R08 exp535	2.02
Artemisinin 50μM R08 exp450	2.08
Atovaquone 15μM R08 exp451	2.09
Rapamycin 10μM R00 exp30	2.12
Mdivi-1 15μM R05 exp217	2.18
LJH685 50μM R08 exp433	2.25
LY2090314 0.003μM R08 exp499	2.26
Bafilomycin-A1 0.009μM R08 exp454	2.38
Clomiphene 4.4μM R02 exp68	2.44
Chloroquine 32μM R08 exp470	2.52
HMS-I2 10μM R06 exp288	3.39
Oligomycin-A 2μM R00 exp25	3.53

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial respiratory chain complex I assembly
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex assembly
mitochondrial inner membrane
mitochondrion organization
cellular protein-containing complex assembly
mitochondrion
protein-containing complex assembly
protein-containing complex subunit organization