NDUFA13

Gene Information

Official Symbol: NDUFA13
Official Name: N/ADH:ubiquinone oxidoreductase subunit A13
Aliases and Previous Symbols: N/A
Entrez ID: 51079
UniProt: Q9P0J0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009].
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091, ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Amiloride 100μM R08 exp447	1.72
Chloramphenicol 20μM R00 exp13	1.79
UMK57 1μM R01 exp59	1.83
Genistein 15μM R07 exp360	1.85
Mubritinib 0.2μM R01 exp48	1.85
Calcium Ionophore 0.4μM R07 exp342	1.89
Benzoate 10000μM R08 exp455	1.93
UM131593 0.2μM R03 exp106	1.98
BML-284 0.09μM R08 exp460	2
HMS-I2 10μM R06 exp288	2.1
Mdivi-1 15μM R05 exp217	2.11
Resveratrol 16μM R03 exp147	2.15
Hydroxychloroquine 30μM R08 exp490	2.17
IWR1 50μM R08 exp495	2.19
AICAR 240μM R05 exp211	2.22
Ribavirin 10μM R01 exp52	2.44
Artemisinin 50μM R08 exp450	2.46
Hydroxyurea 100μM R07 exp329	2.55
Atovaquone 15μM R08 exp451	2.79
Oligomycin-A 2μM R00 exp25	3.27

Gene	Correlation
NDUFC2	0.589
NDUFA2	0.567
NDUFA1	0.55
NDUFS2	0.538
NDUFA11	0.535
NDUFB4	0.533
NDUFA9	0.533
NDUFB11	0.525
ACAD9	0.518
NDUFB9	0.515
NUBPL	0.513
NDUFAF7	0.503
NDUFS8	0.501
NDUFB7	0.5
RTN4IP1	0.499
NDUFA8	0.497
GRSF1	0.496
NDUFC1	0.496
MTO1	0.49
NDUFA3	0.485
NDUFV1	0.476
TIMMDC1	0.476
NDUFS1	0.468
NDUFS5	0.467
NDUFB8	0.466
NDUFA10	0.462
NDUFA6	0.457
NDUFAF3	0.456
NDUFS3	0.451
NDUFS7	0.444
NOA1	0.443
ECSIT	0.443
MTRF1L	0.441
NDUFV2	0.441
TFB1M	0.43
NDUFAF6	0.429
POLG2	0.427
MRPL45	0.427
NDUFB2	0.425
SLC25A51	0.422
MRPS27	0.419
TMEM261	0.418
MRPL43	0.418
MRP63	0.414
RNMTL1	0.414
MRPS21	0.413
NDUFAF4	0.409
NDUFA5	0.409
MTIF2	0.408
WBSCR16	0.405
MRPL3	0.403
METTL17	0.403
C10orf2	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 248
Expression level (log2 read counts): 5.36

Expression Distribution

protein insertion into mitochondrial inner membrane
NADH dehydrogenase activity
mitochondrial respirasome
establishment of protein localization to mitochondrial membrane
cellular response to interferon-beta
protein insertion into mitochondrial membrane
response to interferon-beta
protein insertion into membrane
inner mitochondrial membrane organization
NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I
protein targeting to mitochondrion
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
cellular response to retinoic acid
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
negative regulation of intrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway
mitochondrial respiratory chain complex assembly
mitochondrial membrane
response to retinoic acid
respiratory electron transport chain
reactive oxygen species metabolic process
oxidative phosphorylation
mitochondrial membrane organization
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
regulation of intrinsic apoptotic signaling pathway
cellular respiration
positive regulation of endopeptidase activity
electron transport chain
negative regulation of cell growth
positive regulation of peptidase activity
ATP metabolic process
cellular response to acid chemical
regulation of cysteine-type endopeptidase activity involved in apoptotic process