Ribavirin 10μM R01 exp52

Mechanism of Action

Prodrug metabolized to purine RNA nucleotide mimetic, also inhibits EIF4E

  • Class / Subclass 1: Infectious Disease / Antiviral
  • Class / Subclass 2: Metabolism / Antimetabolite
  • Class / Subclass 3: DNA Damage, Repair and Replication / Reverse Transcriptase Inhibitor

Technical Notes

Compound References

  • PubChem Name: Ribavirin
  • Synonyms: ICN-1229
  • CAS #: 36791-04-5
  • PubChem CID: 37542
  • IUPAC: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
  • INCHI Name: InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
  • INCHI Key: IWUCXVSUMQZMFG-AFCXAGJDSA-N
  • Molecular Weight: 244.2
  • Canonical SMILES: C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
  • Isomeric SMILES: C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N
  • Molecular Formula: C8H12N4O5

Compound Supplier

  • Supplier Name: Kemprotec Ltd
  • Catalog #: K-1104
  • Lot #: 170221

Compound Characterization

Characterization data not available.

Dose Response Curve

  • Platform ID: Ribavirin
  • Min: -21.0950; Max: 37.2497





IC Concentration (µM)
IC10 N/A
IC20 30.6995
IC30 36.4591
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 01
  • Dose: 10µM
  • Days of incubation: 8
  • Doublings: 6.5
  • Numbers of reads: 9955062

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
3/1ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1