DHX33

Gene Information

Official Symbol: DHX33
Official Name: DEAH-box helicase 33
Aliases and Previous Symbols: N/A
Entrez ID: 56919
UniProt: Q9H6R0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization. {ECO:0000269|PubMed:21930779}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-2.42
Ribavirin 10μM R01 exp52	-2.32
Golgicide-A 4μM R03 exp122	-2.14
Calcium Ionophore 0.4μM R07 exp342	-2.11
2-Methoxyestradiol 0.2μM R01 exp40	-2.1
Parthenolide 2.5μM R05 exp238	-1.93
A-196 10μM R03 exp114	-1.86
PFI-2 4μM R05 exp239	-1.86
Nicotinamide 1000μM R03 exp101	-1.75
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.71

Global Fraction of Cell Lines Where Essential: 696/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	25/26
breast	27/33
central nervous system	54/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	20/21
liver	20/20
lung	71/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	12/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 286
Expression level (log2 read counts): 7.04

Expression Distribution

Helicase C
HA2
OB NTP bind
DEAD

rDNA binding
positive regulation of NLRP3 inflammasome complex assembly
NLRP3 inflammasome complex
ribosomal large subunit binding
regulation of NLRP3 inflammasome complex assembly
3-5 RNA helicase activity
positive regulation of transcription by RNA polymerase I
regulation of transcription by RNA polymerase I
activating transcription factor binding
double-stranded RNA binding
positive regulation of type I interferon production
regulation of type I interferon production
translational initiation
positive regulation of NF-kappaB transcription factor activity
mRNA binding
positive regulation of protein complex assembly
positive regulation of DNA-binding transcription factor activity
translation
peptide biosynthetic process
regulation of DNA-binding transcription factor activity
positive regulation of cytokine production
regulation of protein complex assembly
positive regulation of cellular component biogenesis
amide biosynthetic process
peptide metabolic process
positive regulation of MAPK cascade
regulation of cytokine production
regulation of MAPK cascade
cellular amide metabolic process
nucleolus
regulation of cellular component biogenesis
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of cellular component organization
positive regulation of protein modification process
RNA binding
organonitrogen compound biosynthetic process