Parthenolide 2.5μM R05 exp238
Mechanism of Action
Sesquiterpene lactone with attributed activities in microtubule function, NF-κB activation, HDAC1 inhibition, MDM2 ubiquitination. Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew
- Class / Subclass 1: Cell Cycle / Microtubule Poison
- Class / Subclass 2: Uncharacterized Mechanism / Natural Product
- Class / Subclass 3: Signal Transduction / Apoptosis Inducer
Technical Notes
Compound References
- PubChem Name: (-)-Parthenolide
- Synonyms: (-)-Parthenolide
- CAS #: 20554-84-1
- PubChem CID: 7251185
- IUPAC: (1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one
- INCHI Name: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
- INCHI Key: KTEXNACQROZXEV-PVLRGYAZSA-N
- Molecular Weight: 248.32
- Canonical SMILES: CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
- Isomeric SMILES: C/C/1=C\\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C
- Molecular Formula: C15H20O3
Compound Supplier
- Supplier Name: Tocris Bioscience
- Catalog #: 0610
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C15H20O3 249.14852; found 249.14835
Dose Response Curve
- Platform ID: Parthenolide
- Min: 5.0270; Max: 99.5981
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 2.2034 |
| IC30 | 2.4548 |
| IC40 | 2.6822 |
| IC50 | 2.9093 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 05
- Dose: 2.5µM
- Days of incubation: 8
- Doublings: 6.3
- Numbers of reads: 25053361
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 1/0 | Scores |
Parthenolide 2.5μM R05 exp238
