TBCA

Entrez Summary: N/A
UniProt Summary: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Parthenolide 2.5μM R05 exp238	-2.15
Colchicine 0.009μM R05 exp215	-2.11
Isoniazid 100μM R08 exp494	-2.09
Bisphenol S 100μM R08 exp458	-1.93
D-Fructose 10000μM R06 exp279	-1.86
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.82
Methotrexate 0.01μM R08 exp501	-1.81
Cannabidiol 13μM R08 exp465	-1.75
QNZ 0.01μM R08 exp439	-1.75
Nocodazole 0.2μM R00 exp24	1.71
Vitamin-D3 40μM R08 exp536	1.9
Brefeldin A 0.02μM R00 exp8	2.4

Global Fraction of Cell Lines Where Essential: 244/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	9/28
bone	11/26
breast	13/33
central nervous system	12/56
cervix	2/4
colorectal	2/17
esophagus	5/13
fibroblast	1/1
gastric	3/16
kidney	4/21
liver	8/20
lung	29/75
lymphocyte	5/16
ovary	6/26
pancreas	12/24
peripheral nervous system	8/16
plasma cell	7/15
prostate	0/1
skin	7/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	8/29
uterus	1/5

Expression Distribution

post-chaperonin tubulin folding pathway
tubulin complex assembly
beta-tubulin binding
tubulin binding
chaperone binding
microtubule cytoskeleton
protein folding
microtubule
cellular protein-containing complex assembly
nucleolus
RNA binding
protein-containing complex assembly
protein-containing complex subunit organization