Phorbol-12-myristate-13-acetate 0.57μM R08 exp514

Mechanism of Action

Activates PKC isoforms, potent tumour promoter

  • Class / Subclass 1: Signal Transduction / Kinase Activator

Technical Notes

Compound References

  • PubChem Name: Phorbol 12-myristate 13-acetate
  • Synonyms: PMA
  • CAS #: 16561-29-8
  • PubChem CID: 27924
  • IUPAC: [(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate
  • INCHI Name: InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
  • INCHI Key: PHEDXBVPIONUQT-RGYGYFBISA-N
  • Molecular Weight: 616.8
  • Canonical SMILES: CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
  • Isomeric SMILES: CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C
  • Molecular Formula: C8H8HgO2

Compound Supplier

  • Supplier Name: Med Chem Express
  • Catalog #: HY-18739
  • Lot #: 24554

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C36 H56 O8 639.38674; found 639.38537

Dose Response Curve

  • Platform ID: TPA
  • Min: 11.8198; Max: 99.9039





IC Concentration (µM)
IC10 N/A
IC20 7.0489
IC30 8.4531
IC40 9.4877
IC50 10.4307
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 08
  • Dose: 570nM
  • Days of incubation: 8
  • Doublings: 6.2
  • Numbers of reads: 16332845

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
33/33ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1