SETD1B

Gene Information
  • Official Symbol: SETD1B
  • Official Name: SET domain containing 1B, histone lysine methyltransferase
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 23067
  • UniProt: Q9UPS6
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 450
  • Expression level (log2 read counts): 6.45

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1