JQ1 0.01μM R03 exp130
Mechanism of Action
Inhibits BET bromodomain proteins BRD2, BRD3, BRD4, BRDT
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Compound References
- PubChem Name: JQ1 compound
- Synonyms: JQ1
- CAS #: 1268524-70-4
- PubChem CID: 46907787
- IUPAC: tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate
- INCHI Name: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
- INCHI Key: DNVXATUJJDPFDM-KRWDZBQOSA-N
- Molecular Weight: 457
- Canonical SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
- Isomeric SMILES: CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
- Molecular Formula: C23H25ClN4O2S
Compound Supplier
- Supplier Name: Structural Genomics Consortium
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H25ClN4O2S 457.14595; found 457.14708
Dose Response Curve
- Platform ID: JQ1
- Min: 21.2855; Max: 88.2551
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | 0.0017 |
| IC50 | 0.0066 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 10nM
- Days of incubation: 8
- Doublings: 8.1
- Numbers of reads: 9256634
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
JQ1 0.01μM R03 exp130
