HTR1B

Gene Information

Official Symbol: HTR1B
Official Name: 5-hydroxytryptamine receptor 1B
Aliases and Previous Symbols: N/A
Entrez ID: 3351
UniProt: P28222
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:15853772, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:8218242}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LJH685 50μM R08 exp433	-2.24
BI-6727 0.0125μM R03 exp97	-1.81
Vitamin-D3 40μM R08 exp536	1.74
Chloroquine 32μM R08 exp470	1.79
MSC2530818 10μM R07 exp379	1.82
Calcipotriol 5μM R08 exp464	1.83
BRD2 inhibitor II 20μM R07 exp341	1.84
JQ1 0.01μM R03 exp130	1.9
Apcin 50 to 100μM on day4 R04 exp176	2.29
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	2.31

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3384
Expression level (log2 read counts): -7.68

Expression Distribution

7TM GPCR Srsx
7TM GPCR Srx
7tm 1

serotonergic synapse
adenylate cyclase-inhibiting serotonin receptor signaling pathway
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
negative regulation of serotonin secretion
cellular response to temperature stimulus
negative regulation of synaptic transmission, GABAergic
regulation of serotonin secretion
negative regulation of synaptic transmission, glutamatergic
drinking behavior
serotonin binding
G protein-coupled receptor internalization
presynaptic modulation of chemical synaptic transmission
regulation of presynaptic cytosolic calcium ion concentration
desensitization of G protein-coupled receptor signaling pathway
negative adaptation of signaling pathway
adaptation of signaling pathway
negative regulation of neurotransmitter transport
calyx of Held
protein kinase C-activating G protein-coupled receptor signaling pathway
vasoconstriction
regulation of synaptic transmission, GABAergic
response to mineralocorticoid
positive regulation of vascular smooth muscle cell proliferation
G protein-coupled serotonin receptor signaling pathway
neuron cellular homeostasis
G protein-coupled serotonin receptor activity
cellular response to alkaloid
neurotransmitter receptor activity
negative regulation of blood vessel diameter
serotonin receptor signaling pathway
regulation of dopamine secretion
bone remodeling
negative regulation of G protein-coupled receptor signaling pathway
regulation of vascular smooth muscle cell proliferation
response to cocaine
drug binding
integral component of presynaptic membrane
negative regulation of synaptic transmission
regulation of catecholamine secretion
receptor internalization