MSC2530818 10μM R07 exp379

Mechanism of Action

Inhibits CDK8

  • Class / Subclass 1: Gene Regulation / Transcription Inhibitor
  • Class / Subclass 2: Signal Transduction / Kinase Inhibitor

Technical Notes

Compound References

  • PubChem Name: [(2s)-2-(4-Chlorophenyl)pyrrolidin-1-Yl](3-Methyl-1h-Pyrazolo[3,4-B]pyridin-5-Yl)methanone
  • Synonyms: N/A
  • CAS #: 1883423-59-3
  • PubChem CID: 118879529
  • IUPAC: [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)methanone
  • INCHI Name: InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1
  • INCHI Key: ODRITQGYYWHQGM-INIZCTEOSA-N
  • Molecular Weight: 340.8
  • Canonical SMILES: CC1=C2C=C(C=NC2=NN1)C(=O)N3CCCC3C4=CC=C(C=C4)Cl
  • Isomeric SMILES: CC1=C2C=C(C=NC2=NN1)C(=O)N3CCC[C@H]3C4=CC=C(C=C4)Cl
  • Molecular Formula: C18H17ClN4O

Compound Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S8387
  • Lot #: S838701

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C18H17ClN4O 341.11637; found 341.11722

Dose Response Curve

  • Platform ID: MSC2530818
  • Min: -12.4323; Max: 17.9953





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 07
  • Dose: 10µM
  • Days of incubation: 8
  • Doublings: 6.2
  • Numbers of reads: 20433427

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
1/0ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1