RASIP1

Gene Information

Official Symbol: RASIP1
Official Name: Ras interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 54922
UniProt: Q5U651
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS- mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ETC-159 50μM R08 exp480	-1.7
MSC2530818 10μM R07 exp379	1.85
Daidzin 10μM R06 exp280	1.86
CB-5083 0.4μM R08 exp468	1.87
Thimerosal 0.85μM R08 exp529	1.91
INK128 0.2μM R02 exp70	2.04
Cyclosporin-A 0.8μM R07 exp347	2.3
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.63

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3827
Expression level (log2 read counts): -0.12

Expression Distribution

RA
DIL

negative regulation of Rho-dependent protein serine/threonine kinase activity
regulation of Rho-dependent protein serine/threonine kinase activity
positive regulation of integrin activation
negative regulation of membrane permeability
regulation of integrin activation
negative regulation of Rho protein signal transduction
GTPase binding
Golgi stack
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
vasculogenesis
regulation of membrane permeability
negative regulation of autophagy
branching morphogenesis of an epithelial tube
negative regulation of protein serine/threonine kinase activity
regulation of Rho protein signal transduction
morphogenesis of a branching epithelium
morphogenesis of a branching structure
cell-cell junction
negative regulation of protein kinase activity
regulation of Ras protein signal transduction
negative regulation of kinase activity
positive regulation of protein complex assembly
negative regulation of cellular catabolic process
negative regulation of transferase activity
epithelial tube morphogenesis
negative regulation of catabolic process
angiogenesis
regulation of autophagy
regulation of small GTPase mediated signal transduction
negative regulation of protein phosphorylation
blood vessel morphogenesis
morphogenesis of an epithelium
negative regulation of phosphorylation
regulation of protein complex assembly
regulation of GTPase activity
blood vessel development
negative regulation of intracellular signal transduction
vasculature development
regulation of protein serine/threonine kinase activity