ETC-159 50μM R08 exp480 [The Human Chemical-Genetic Interaction Map Project]

Inhibits PORCN palmitoyl transferase that modifies WNT ligands

Class / Subclass 1: Signal Transduction / Other Inhibitor

Compound References

PubChem Name: Etc-159
Synonyms: ETC-1922159
CAS #: 1638250-96-0
PubChem CID: 86280523
IUPAC: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide
INCHI Name: InChI=1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
INCHI Key: QTRXIFVSTWXRJJ-UHFFFAOYSA-N
Molecular Weight: 391.4
Canonical SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4
Isomeric SMILES: N/A
Molecular Formula: C19H17N7O3

Compound Supplier

Supplier Name: Med Chem Express
Catalog #: HY-18988
Lot #: 18685

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C19H17N7O3 392.14656; found 392.14729

Dose Response Curve

Platform ID: ETC159
Min: -27.6061; Max: 13.1023

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 08
Dose: 50µM
Days of incubation: 8
Doublings: 5.3
Numbers of reads: 16937241

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
12/3	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
LCMT1	-3.93	<0.01
GPR107	-3.92	<0.01
ARL1	-3.56	<0.01
PPME1	-3.55	<0.01
PPP6C	-3.52	<0.01
SLC39A9	-3.29	<0.01
TCF4	-3.24	<0.01
BACH2	-2.90	0.01
KCTD5	-2.88	<0.01
PGGT1B	-2.77	<0.01
MSL1	-2.59	0.05
CSK	-2.51	0.03
CNOT8	-2.41	0.05
PPP2CA	-2.33	0.14
PDCD6IP	-2.28	0.10
DARS2	-2.22	0.46
ATP2B1	-2.20	0.24
RAPGEF3	-2.19	0.14
RFWD2	-2.16	0.16
ACTB	-2.13	0.18
DLD	-2.12	0.30
CTDSPL2	-2.10	0.30
ZNF445	-2.09	0.31
KIAA1432	-2.06	0.32
SMG9	-2.05	0.35
FAM134A	-2.02	0.30
SS18	-1.99	0.30
LAMTOR4	-1.99	0.30
XPR1	-1.99	0.30
SRRD	-1.96	0.32
SLCO1B3	1.97	0.39
LSR	1.98	0.62
ZSCAN22	1.98	0.39
U2AF2	1.99	0.62
OR8U8	1.99	0.72
TRIM37	2.00	0.36
NAT10	2.01	0.62
MTRNR2L4	2.03	0.79
RTP2	2.04	0.32
NSMAF	2.06	0.30
C21orf2	2.08	0.29
GLE1	2.11	0.64
RRM2	2.15	0.74
MS4A13	2.17	0.73
HNRNPAB	2.18	0.20
SCEL	2.21	0.18
CUL1	2.24	0.18
BAZ2A	2.25	0.26
KMT2D	2.35	0.11
USP37	2.35	0.18
SLC1A6	2.35	0.11
ATP8B2	2.39	0.26
SLC7A1	2.44	0.36
ETFB	2.47	0.07
FDPS	2.68	0.07
NOP58	2.71	0.10
PSMB8	2.72	0.04
SRM	2.83	0.03
NUMA1	2.94	0.06
PCGF1	3.10	<0.01

Screen	Correlation	Plot
Vincristine 0.0005μM R04 exp190	0.057	View
Bisphenol A 100μM R06 exp269	0.061	View
EPZ-5676 30μM R05 exp233	0.055	View
Benzoate 10000μM R08 exp455	0.051	View

Last modified: 2026/01/15 21:36
by 127.0.0.1