Benzoate 10000μM R08 exp455 [The Human Chemical-Genetic Interaction Map Project]

Food additive (E211), bacteriostatic and fungistatic

Class / Subclass 1: Environmental Stresses / Food Preservative

Compound References

PubChem Name: Sodium benzoate
Synonyms: N/A
CAS #: 532-32-1
PubChem CID: 517055
IUPAC: sodium;benzoate
INCHI Name: InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1
INCHI Key: WXMKPNITSTVMEF-UHFFFAOYSA-M
Molecular Weight: 144.1
Canonical SMILES: C1=CC=C(C=C1)C(=O)[O-].[Na+]
Isomeric SMILES: N/A
Molecular Formula: C7H5O2Na

Compound Supplier

Supplier Name: Med Chem Express
Catalog #: HY-Y1316
Lot #: 26735

Compound Characterization

HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C7H6O2 145.026; found 145.02692

Dose Response Curve

Platform ID: Benzoate
Min: -0.6897; Max: 28.0815

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 08
Dose: 10000µM
Days of incubation: 8
Doublings: 3.9
Numbers of reads: 13097136

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
14/4	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
RSRC2	-4.69	<0.01
CSK	-3.16	<0.01
MNS1	-3.11	0.02
PAG1	-2.90	0.02
MTF2	-2.81	0.03
DERL2	-2.76	0.03
UBE2J1	-2.76	0.02
ARF1	-2.62	0.03
LAMTOR4	-2.59	0.03
OPA1	-2.57	0.04
SEPSECS	-2.53	0.05
GCLM	-2.53	0.03
HSD17B10	-2.52	0.05
GCLC	-2.49	0.03
SLC7A11	-2.49	0.03
CARM1	-2.48	0.03
SHISA8	-2.34	0.10
CSDE1	-2.31	0.06
BCL2	-2.31	0.06
SMG7	-2.28	0.12
SEC31A	-2.22	0.10
PDCD10	-2.22	0.10
NID1	-2.21	0.10
BACH2	-2.17	0.20
DNAJC3	-2.16	0.12
TCF4	-2.13	0.13
TSC1	-2.08	0.25
ATP6V0A2	-2.06	0.27
VPS52	-2.06	0.54
NDUFA2	-2.02	0.30
G6PD	2.04	0.24
SRM	2.06	0.24
KANSL3	2.08	0.24
IPO13	2.10	0.34
SF3A2	2.14	0.24
HDAC7	2.15	0.17
MFAP1	2.16	0.24
NCBP1	2.17	0.38
PIK3CD	2.17	0.17
SBNO2	2.20	0.24
EXOSC6	2.21	0.36
GGT7	2.22	0.17
RPL11	2.24	0.40
NOL9	2.24	0.25
R3HDM1	2.26	0.15
DYSF	2.28	0.17
FAM98B	2.28	0.17
MARCH5	2.29	0.17
BAK1	2.30	0.13
HSPA13	2.42	0.10
SHMT2	2.43	0.17
CD19	2.48	0.11
ZCCHC8	2.53	0.10
RBM26	2.56	0.10
ZBTB7A	2.62	0.05
HEXIM1	2.65	0.05
MTRNR2L4	2.68	0.46
ARID4B	2.74	0.05
SLC25A1	2.99	<0.01
RHOH	3.56	<0.01

Screen	Correlation	Plot
Ethanol 0.01 R05 exp234	0.082	View
Thapsigargin 0.005μM R07 exp407	0.062	View
∆-9-Tetrahydrocannabinol 30μM R08 exp445	0.059	View
Sulforaphane 9μM R08 exp525	0.057	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.052	View
ETC-159 50μM R08 exp480	0.051	View
B02 10μM R08 exp453	0.064	View
5-Azacytidine 2μM R07 exp330	0.056	View

Last modified: 2026/01/15 21:36
by 127.0.0.1