∆-9-Tetrahydrocannabinol 30μM R08 exp445
Mechanism of Action
Agonist of CB1 and CB2 cannabinoid receptors
- Class / Subclass 1: Environmental Stresses / Controlled Substance
- Class / Subclass 2: Signal Transduction / GPCR Agonist
Technical Notes
Compound References
- PubChem Name: Dronabinol
- Synonyms: N/A
- CAS #: 1972-08-3
- PubChem CID: 16078
- IUPAC: (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol
- INCHI Name: InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
- INCHI Key: CYQFCXCEBYINGO-IAGOWNOFSA-N
- Molecular Weight: 314.5
- Canonical SMILES: CCCCCC1=CC(=C2C3C=C(CCC3C(OC2=C1)(C)C)C)O
- Isomeric SMILES: CCCCCC1=CC(=C2[C@@H]3C=C(CC[C@H]3C(OC2=C1)(C)C)C)O
- Molecular Formula: C21H30O2
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: T293200
- Lot #: 7-YEN-94-6
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H30O2 315.23186; found 315.23143
Dose Response Curve
- Platform ID: THC
- Min: -16.2079; Max: 99.4826
| IC | Concentration (µM) |
|---|---|
| IC10 | 26.9000 |
| IC20 | 32.2200 |
| IC30 | 36.3200 |
| IC40 | 40.0700 |
| IC50 | 43.8500 |
| IC60 | 47.9900 |
| IC70 | 52.9400 |
| IC80 | 59.6900 |
| IC90 | 71.4800 |
Screen Summary
- Round: 08
- Dose: 30µM
- Days of incubation: 8
- Doublings: 2.5
- Numbers of reads: 15258071
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 17/10 | Scores |
∆-9-Tetrahydrocannabinol 30μM R08 exp445
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs PU-H71 1μM R08 exp515
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs MK2206 4μM R08 exp504
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs WYE-354 6μM R02 exp90
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs FK-506 30μM R07 exp359
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Rotenone 0.07μM R08 exp431
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Doxorubicin 0.02μM R08 exp478
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Thimerosal 0.85μM R08 exp529
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Hippuristanol 0.12μM R08 exp488
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Dorsomorphin 5μM R07 exp357
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Q15 1 to 2μM on day4 R04 exp164
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Hippuristanol 0.12μM R08 exp489 no dilution day6
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Milciclib 2μM R08 exp502
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs UM0129480 7μM R02 exp85
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Ibrutinib 10μM R08 exp442
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs iCRT14 30μM R08 exp492
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs QNZ 0.01μM R08 exp439
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Q15 2.7μM R02 exp79
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Lapatinib 5μM R01 exp47
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs FTY720 3μM R08 exp483
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Sulforaphane 9μM R08 exp525
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Tubacin 1.6μM R07 exp416
Cannabidiol 20μM R08 exp466 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
BVD-523 15μM R02 exp67 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
Amiloride 100μM R08 exp447 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
Bisphenol A 100μM R06 exp269 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
CB-5083 0.4μM R08 exp468 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
Cryptotanshinone 12μM R05 exp227 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
CAY10603 0.55μM R08 exp467 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
Cannabidiol 13μM R08 exp465 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
Benzoate 10000μM R08 exp455 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
Centrinone 0.5μM R07 exp343 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
Citral 75μM R06 exp275 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
BS-181 20μM R08 exp461 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
Chlorpromazine 10μM R07 exp344 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
CB-839 10μM R05 exp224 vs ∆-9-Tetrahydrocannabinol 30μM R08 exp445
