VPS25
Gene Information
- Official Symbol: VPS25
- Official Name: vacuolar protein sorting 25 homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 84313
- UniProt: Q9BRG1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. {ECO:0000269|PubMed:18723511}.
Pfam Domains GO Terms
Pfam Domains
| ESCRT-II |
GO Terms
| ESCRT II complex |
| protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| late endosome to vacuole transport via multivesicular body sorting pathway |
| negative regulation of epidermal growth factor-activated receptor activity |
| late endosome to vacuole transport |
| ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| endosome transport via multivesicular body sorting pathway |
| regulation of epidermal growth factor-activated receptor activity |
| negative regulation of protein tyrosine kinase activity |
| multivesicular body assembly |
| multivesicular body organization |
| multivesicular body sorting pathway |
| negative regulation of epidermal growth factor receptor signaling pathway |
| establishment of protein localization to vacuole |
| negative regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of ERBB signaling pathway |
| negative regulation of signaling receptor activity |
| protein localization to vacuole |
| endosome organization |
| regulation of epidermal growth factor receptor signaling pathway |
| regulation of protein tyrosine kinase activity |
| regulation of ERBB signaling pathway |
| protein N-terminus binding |
| vacuolar transport |
| macroautophagy |
| regulation of signaling receptor activity |
| structural molecule activity |
| endosome membrane |
| negative regulation of protein kinase activity |
| endosomal transport |
| negative regulation of kinase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| autophagy |
| process utilizing autophagic mechanism |
| negative regulation of transferase activity |
| vesicle organization |
| negative regulation of protein phosphorylation |
| endomembrane system organization |
| establishment of protein localization to organelle |
| negative regulation of phosphorylation |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| proteolysis involved in cellular protein catabolic process |
| negative regulation of protein modification process |
| cellular protein catabolic process |
| protein catabolic process |
| protein localization to organelle |
| organelle assembly |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| protein homodimerization activity |
| cellular macromolecule catabolic process |
| regulation of transferase activity |
| intracellular protein transport |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of signal transduction |
| proteolysis |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| negative regulation of response to stimulus |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 734/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 13/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 119
- Expression level (log2 read counts): 4.39
Expression Distribution
VPS25 Expression in NALM6 Cells: 4.39
