MS023 2μM R03 exp134

Inhibits protein arginine N-methyltransferase PRMT1

Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor

Compound References

PubChem Name: MS023 (dihydrochloride)
Synonyms: N/A
CAS #: 1992047-64-9
PubChem CID: 121513886
IUPAC: N'-methyl-N'-[[4-(4-propan-2-yloxyphenyl)-1H-pyrrol-3-yl]methyl]ethane-1,2-diamine;dihydrochloride
INCHI Name: InChI=1S/C17H25N3O.2ClH/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18;;/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3;2*1H
INCHI Key: HCNXCUFNZWGILO-UHFFFAOYSA-N
Molecular Weight: 360.3
Canonical SMILES: CC(C)OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN.Cl.Cl
Isomeric SMILES: N/A
Molecular Formula: C17H27Cl2N3O

Compound Supplier

Supplier Name: Structural Genomics Consortium
Catalog #: N/A
Lot #: N/A

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H25N3O 288.20704; found 288.20735

Dose Response Curve

Platform ID: MS023
Min: -6.0031; Max: 44.7664

IC	Concentration (µM)
IC10	N/A
IC20	3.5114
IC30	7.8192
IC40	15.0721
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 2µM
Days of incubation: 8
Doublings: 3.6
Numbers of reads: 13885666

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
5/78	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
LRRC63	-3.09	0.34
CPSF7	-3.06	0.03
MTF2	-2.91	0.03
GIGYF2	-2.77	0.08
CSK	-2.70	0.03
RHOA	-2.68	0.03
VPS13D	-2.67	0.09
PRMT1	-2.65	0.24
CNOT8	-2.61	0.04
EIF3L	-2.59	0.11
ANKRD40	-2.52	0.11
SRM	-2.48	0.07
BCL2L1	-2.46	0.10
CHTOP	-2.42	0.08
VPS25	-2.36	0.38
HAPLN1	-2.36	0.09
NMT1	-2.32	0.14
TSTA3	-2.30	0.21
UBE2N	-2.27	0.11
RNF40	-2.26	0.16
SMS	-2.25	0.11
GOLGA8H	-2.24	0.44
KPNA2	-2.23	0.11
XPR1	-2.23	0.11
ARFRP1	-2.22	0.27
WDR77	-2.21	0.27
RAPGEF2	-2.16	0.15
KIDINS220	-2.14	0.16
GPR15	-2.12	0.16
EFR3A	-2.11	0.24
ASUN	2.96	<0.01
ELP6	3.00	<0.01
VDAC2	3.06	<0.01
HEATR3	3.08	<0.01
RHOH	3.10	<0.01
PQBP1	3.11	<0.01
GNAS	3.13	<0.01
MEMO1	3.14	<0.01
BCL2L11	3.23	<0.01
MLST8	3.28	<0.01
ANKMY2	3.28	<0.01
RICTOR	3.31	<0.01
PLAA	3.33	<0.01
DPH5	3.40	<0.01
PACS1	3.44	<0.01
TADA2A	3.53	<0.01
MOCS3	3.63	<0.01
SF1	3.71	<0.01
APAF1	3.74	<0.01
DPH3	3.77	<0.01
AKT2	3.90	<0.01
KMT2D	3.97	<0.01
UBQLN1	4.01	<0.01
ATIC	4.07	<0.01
NR2C2AP	4.27	<0.01
PIK3CD	4.31	<0.01
MAPKAP1	4.40	<0.01
BAK1	4.63	<0.01
C7orf26	4.87	<0.01
TAF15	5.14	<0.01

Screen	Correlation	Plot
MS023 7μM R03 exp135	0.217	View
Staurosporine 0.02μM R08 exp524	0.094	View
Olaparib 4μM R08 exp512	0.09	View
Sulforaphane 9μM R08 exp525	0.084	View
Trimetrexate 0.03μM R08 exp535	0.079	View
Nifuroxazide 5μM R03 exp102	0.072	View
UM0129480 7μM R02 exp85	0.071	View
SNS-032 15μM R08 exp443	0.068	View
Milciclib 2μM R08 exp502	0.067	View
THZ1 0.06μM R08 exp531	0.064	View
Mitomycin-C 0.06μM R08 exp503	0.06	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.06	View
RO-3307 4.7μM R02 exp80	0.059	View
PU-H71 1μM R08 exp515	0.058	View
Rucaparib 6.5μM R08 exp520	0.055	View
Nutlin-3A 1.6μM R06 exp294	0.054	View
Tanespimycin 14μM R08 exp527	0.052	View
Hippuristanol 0.12μM R08 exp489 no dilution day6	0.185	View
Hippuristanol 0.12μM R08 exp488	0.162	View
AICAR 240μM R03 exp116	0.154	View
Ethanol 0.01 R05 exp234	0.126	View
Benzoate 20000μM R08 exp456	0.108	View
Aphidicolin 0.4μM R08 exp440	0.099	View
AICAR 240μM R05 exp211	0.094	View
GSK626616 14μM R08 exp485	0.092	View
2-Deoxy-D-glucose 800μM R05 exp214	0.08	View
MLN-4924 0.2μM R00 exp21	0.079	View
Citral 50μM R06 exp274	0.078	View
Artemisinin 50μM R08 exp450	0.076	View
CR131-b 0.005μM R08 exp474	0.076	View
JQ1 0.8μM R08 exp435	0.072	View
Bleomycin 5μM R08 exp459	0.071	View
5-Azacytidine 2μM R07 exp330	0.068	View
6-Thio-2-deoxyguanosine 2μM R06 exp259	0.067	View
Latrunculin-B 10μM R07 exp374	0.067	View
Amiloride 100μM R08 exp447	0.06	View
Doxorubicin 0.02μM R08 exp478	0.06	View
Actinomycin-D 0.001μM R00 exp3	0.058	View
ML-792 0.2μM R08 exp505	0.057	View
Lead acetate 2000μM R08 exp497	0.057	View
Lead acetate 2000μM R08 exp498 no dilution day6	0.056	View
LY2090314 0.003μM R08 exp500 no dilution day6	0.054	View
5-Fluorouracil 20μM R00 exp2	0.053	View
Etoposide 1μM R00 exp19	0.052	View
Arsenate 40μM R06 exp264	0.052	View
GSK-J4 1-1.25μM to day4 R07 exp363	0.052	View
Bortezomib 0.005μM R00 exp6	0.051	View
Etoposide 0.3μM R05 exp199	0.051	View

GO Term	Fold Change	Genes
TORC2 complex	207.24	MAPKAP1,RICTOR,MLST8
tRNA wobble uridine modification	103.62	DPH3,MOCS3,ELP6

MS023 2μM R03 exp134

Mechanism of Action

Technical Notes

Compound References

Compound Supplier

Compound Characterization

Dose Response Curve

Screen Summary

Screen Results