Benzoate 20000μM R08 exp456

Food additive (E211), bacteriostatic and fungistatic

Class / Subclass 1: Environmental Stresses / Food Preservative

Compound References

PubChem Name: Sodium benzoate
Synonyms: N/A
CAS #: 532-32-1
PubChem CID: 517055
IUPAC: sodium;benzoate
INCHI Name: InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1
INCHI Key: WXMKPNITSTVMEF-UHFFFAOYSA-M
Molecular Weight: 144.1
Canonical SMILES: C1=CC=C(C=C1)C(=O)[O-].[Na+]
Isomeric SMILES: N/A
Molecular Formula: C7H5O2Na

Compound Supplier

Supplier Name: Med Chem Express
Catalog #: HY-Y1316
Lot #: 26735

Compound Characterization

HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C7H6O2 145.026; found 145.02692

Dose Response Curve

Platform ID: Benzoate
Min: -0.6897; Max: 28.0815

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 08
Dose: 20000µM
Days of incubation: 8
Doublings: -0.0
Numbers of reads: 15983785

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/63	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
LHFP	-2.62	0.20
HMGCR	-2.45	0.53
EXOSC3	-2.40	0.28
DNM2	-2.38	0.67
METTL13	-2.36	0.22
ZNF106	-2.34	0.22
ZFAND5	-2.33	0.22
CCIN	-2.33	0.22
NFS1	-2.31	0.67
GTF2B	-2.27	0.65
PPM1G	-2.26	0.37
SYNCRIP	-2.26	0.53
SUPT6H	-2.21	0.53
ZDHHC2	-2.21	0.32
LOC81691	-2.19	0.53
NID2	-2.17	0.34
SH3BP1	-2.12	0.53
PNPLA2	-2.12	0.37
COL2A1	-2.08	0.53
PHF15	-2.03	0.53
MEF2D	-2.03	0.53
CNOT3	-2.02	0.61
VPREB1	-2.02	0.53
RPS23	-2.01	0.53
NUP43	-2.01	0.53
SMG5	-1.99	0.75
PSKH1	-1.98	0.53
MAU2	-1.97	0.75
KIAA1549	-1.96	0.53
SF3A1	-1.95	0.67
MAPKAPK5	2.96	<0.01
SLC4A7	2.96	<0.01
CD19	2.98	<0.01
KCTD5	2.99	0.00
DOHH	2.99	<0.01
HCCS	3.02	<0.01
ALAS1	3.12	<0.01
FLCN	3.14	0.00
CD81	3.15	0.00
THG1L	3.19	0.00
LAMTOR4	3.30	0.00
MLST8	3.32	0.00
BCL2L11	3.40	0.00
TAF4	3.45	0.00
GMPPB	3.70	<0.01
CASP9	3.70	0.00
RICTOR	3.90	0.00
MS4A13	3.91	0.02
GNAS	3.96	0.00
MAPKAP1	4.04	0.00
MCL1	4.44	0.00
APAF1	4.55	0.00
PLAA	4.69	0.00
AHCYL1	5.07	0.00
NSD1	5.07	0.00
FAF2	5.36	0.00
VDAC2	6.41	0.00
UBQLN1	6.91	0.00
BAK1	7.87	0.00
MARCH5	7.88	0.00

Screen	Correlation	Plot
Bleomycin 5μM R08 exp459	0.166	View
Etoposide 0.3μM R05 exp199	0.162	View
Mitomycin-C 0.06μM R08 exp503	0.156	View
Hippuristanol 0.12μM R08 exp489 no dilution day6	0.149	View
Hippuristanol 0.12μM R08 exp488	0.142	View
MS023 7μM R03 exp135	0.139	View
RO-3307 4.7μM R02 exp80	0.137	View
THZ1 0.06μM R08 exp531	0.136	View
Staurosporine 0.02μM R08 exp524	0.132	View
CI-1040 9.5μM R08 exp472	0.13	View
Doxorubicin 0.02μM R08 exp478	0.122	View
SNS-032 15μM R08 exp443	0.117	View
Olaparib 4μM R08 exp512	0.113	View
Pimelic-diphenylamide-106 5μM R00 exp28	0.111	View
MS023 2μM R03 exp134	0.108	View
Rotenone 20μM R00 exp34	0.107	View
Dinaciclib 0.007μM R07 exp355	0.103	View
GSK626616 14μM R08 exp485	0.101	View
Etoposide 1μM R00 exp19	0.1	View
Ethanol 0.01 R05 exp234	0.097	View
PU-H71 1μM R08 exp515	0.095	View
Tanespimycin 14μM R08 exp527	0.086	View
Dorsomorphin 5μM R07 exp357	0.085	View
CR131-b 0.005μM R08 exp474	0.084	View
MLN-4924 2μM R00 exp22	0.083	View
MLN-4924 0.2μM R00 exp21	0.082	View
Sulforaphane 9μM R08 exp526 no dilution day6	0.079	View
Sulforaphane 9μM R08 exp525	0.078	View
JQ1 0.8μM R08 exp435	0.075	View
Thimerosal 0.85μM R08 exp529	0.072	View
UM0129480 7μM R02 exp85	0.07	View
Vinblastine 0.2μM R03 exp108	0.068	View
Deferoxamine 11μM R07 exp350	0.066	View
GSK461364A 0.1μM R03 exp126	0.065	View
LY2090314 0.003μM R08 exp500 no dilution day6	0.059	View
UM131593 0.2μM R03 exp106	0.059	View
Lead acetate 2000μM R08 exp498 no dilution day6	0.058	View
Quercetin 20μM R08 exp517	0.058	View
CB-5083 0.4μM R08 exp468	0.057	View
Nutlin-3A 1.6μM R06 exp294	0.056	View
DABN racemic mixture R03 exp93	0.055	View
Lead acetate 2000μM R08 exp497	0.054	View
Diepoxybutane 3μM R07 exp354	0.052	View
Latrunculin-B 10μM R07 exp374	0.052	View
Trimetrexate 0.03μM R08 exp535	0.051	View
GSK-J4 1.5μM R08 exp441	0.051	View
6-Thio-2-deoxyguanosine 2μM R06 exp259	0.16	View
5-Fluorouracil 20μM R00 exp2	0.153	View
Aphidicolin 0.4μM R08 exp440	0.152	View
AICAR 240μM R05 exp211	0.128	View
Actinomycin-D 0.001μM R00 exp3	0.127	View
AICAR 240μM R03 exp116	0.104	View
Atovaquone 15μM R08 exp451	0.096	View
Ammonium tetrathiomolybdate 10μM R08 exp448	0.075	View
Artemisinin 50μM R08 exp450	0.072	View
42°C R08 exp539	0.062	View

GO Term	Fold Change	Genes
apoptosome	552.30	APAF1,CASP9
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	220.92	APAF1,CASP9
TORC2 complex	207.11	MAPKAP1,RICTOR,MLST8
Bcl-2 family protein complex	184.10	BAK1,MCL1,BCL2L11
TOR signaling	78.90	MAPKAP1,RICTOR,MLST8,LAMTOR4,FLCN
positive regulation of mitochondrial membrane permeability	59.18	BAK1,VDAC2,BCL2L11
positive regulation of membrane permeability	53.45	BAK1,VDAC2,BCL2L11
extrinsic apoptotic signaling pathway in absence of ligand	51.78	BAK1,MCL1,BCL2L11
signal transduction in absence of ligand	51.78	BAK1,MCL1,BCL2L11
apoptotic mitochondrial changes	39.45	BAK1,VDAC2,MCL1,BCL2L11
intrinsic apoptotic signaling pathway in response to DNA damage	31.12	BAK1,MCL1,CASP9,BCL2L11
intrinsic apoptotic signaling pathway	20.71	BAK1,APAF1,MCL1,CASP9,BCL2L11,FLCN
regulation of TOR signaling	20.46	RICTOR,MLST8,LAMTOR4,FLCN,MAPKAPK5
mitochondrial outer membrane	16.01	MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L
regulation of intrinsic apoptotic signaling pathway	15.96	UBQLN1,VDAC2,MCL1,BCL2L11,FLCN
organelle outer membrane	14.10	MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L
outer membrane	13.92	MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L
apoptotic signaling pathway	12.55	BAK1,VDAC2,APAF1,MCL1,CASP9,BCL2L11,FLCN
mitochondrial membrane	6.27	MARCHF5,BAK1,VDAC2,MCL1,BCL2L11,THG1L,ALAS1,HCCS

Benzoate 20000μM R08 exp456

Mechanism of Action

Technical Notes

Compound References

Compound Supplier

Compound Characterization

Dose Response Curve

Screen Summary

Screen Results